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Comment
. 2023 Sep 21;30(9):1006-1008.
doi: 10.1016/j.chembiol.2023.08.015.

Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors

Thamara Nishida Xavier da Silva  1 , José Pedro Friedmann Angeli  2
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Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors

Thamara Nishida Xavier da Silva et al. Cell Chem Biol. .
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Abstract

The report of heightened lipid peroxidation has shone a spotlight on vulnerabilities within challenging cancers. In this context, FSP1 emerges as a pivotal regulator, actively countering the destructive effects of lipid peroxidation. In a groundbreaking development detailed in the latest issue of Cell Chemical Biology, Hendricks et al. unveil FSEN1, a potent inhibitor of FSP1. The discovery of FSEN1 holds tremendous promise as it synergizes with GPX4 inhibitors, in addition to several FDA-approved drugs, amplifying their capacity to induce ferroptosis in resistant cancer cells. This represents a significant stride towards ferroptosis-based strategies in preclinical settings.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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