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Comment
. 2023 Sep 21;30(9):1009-1011.
doi: 10.1016/j.chembiol.2023.07.020.

Repurposing SGLT2 inhibitors for autoimmune diseases? YES, WE MAY!

Michelangelo Certo  1 , Jennifer Niven  2 , Claudio Mauro  3
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Repurposing SGLT2 inhibitors for autoimmune diseases? YES, WE MAY!

Michelangelo Certo et al. Cell Chem Biol. .
Free article

Abstract

T cells play a key role in driving autoimmunity, with alterations in metabolism powering their effector function. In the July 11 issue of Cell Metabolism, Jenkins et al.1 describe how a type 2 diabetes drug, canagliflozin, can be repurposed for the treatment of autoimmune disorders through metabolic reprogramming of the T cell response.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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  • Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity.
    Jenkins BJ, Blagih J, Ponce-Garcia FM, Canavan M, Gudgeon N, Eastham S, Hill D, Hanlon MM, Ma EH, Bishop EL, Rees A, Cronin JG, Jury EC, Dimeloe SK, Veale DJ, Thornton CA, Vousden KH, Finlay DK, Fearon U, Jones GW, Sinclair LV, Vincent EE, Jones N. Jenkins BJ, et al. Cell Metab. 2023 Jul 11;35(7):1132-1146.e9. doi: 10.1016/j.cmet.2023.05.001. Epub 2023 May 24. Cell Metab. 2023. PMID: 37230079

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