Comment
doi: 10.1016/j.kint.2023.07.011.
Suppressing succinate accumulation during ischemia protects the kidney from IRI
Affiliations
- PMID: 37739613
- DOI: 10.1016/j.kint.2023.07.011
Item in Clipboard
Comment
Suppressing succinate accumulation during ischemia protects the kidney from IRI
Kidney Int.
2023 Oct.
Abstract
Previous studies have indicated that succinate accumulation during kidney ischemia, and its oxidation during reperfusion, results in the production of excessive reactive oxygen species, mitochondrial dysfunction, and kidney injury. In this issue, Oh et al. have reported that pyruvate dehydrogenase kinase 4 (PDK4) inhibition in proximal tubules ameliorates kidney ischemia/reperfusion injury via suppressed succinate accumulation. This study suggests that PDK4 inhibition is a promising new treatment strategy for ischemic acute kidney injury.
Copyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Comment on
-
Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.Kidney Int. 2023 Oct;104(4):724-739. doi: 10.1016/j.kint.2023.06.022. Epub 2023 Jul 1. Kidney Int. 2023. PMID: 37399974
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
