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Comment
. 2024 Jul 11;73(8):1397-1400.
doi: 10.1136/gutjnl-2023-330497.

Exploring the impact of gut microbial metabolites on inactivated SARS-CoV-2 vaccine efficacy during pregnancy and mother-to-infant antibody transfer

Xi Fu #  1 , Bingqian Du #  1 , Pei-An Chen  1 , Aga Shama  1 , Baolan Chen  1 , Xi Zhang  1 , Xue Han  1 , Yingxia Xu  1 , Yajie Gong  1 , Xia Zeng  1 , Chongzhen Sun  1 , Wenhan Yang  1 , Xiaohui Xing  1 , Zhongjun Li  2 , Yanyan Fu  3 , Dongyun Ke  3 , Niping Wang  3 , Yun Xia  1 , Yu Sun  4 , Qingsong Chen  5
Affiliations
Comment

Exploring the impact of gut microbial metabolites on inactivated SARS-CoV-2 vaccine efficacy during pregnancy and mother-to-infant antibody transfer

Xi Fu et al. Gut. .
No abstract available

Keywords: INTESTINAL MICROBIOLOGY.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Enriched maternal gut microbial taxa, functional pathways and metabolites in three groups: negative neutralising antibody (NAb), weak positive NAb and strong positive NAb. (A) Enriched maternal gut microbial taxa were identified by LEfSe (linear discriminant analysis effect size), with only taxa with linear discriminant analysis (LDA) score>2 were presented in the figure. (B) The relative abundance of major gut microbial species. (C) Enriched gut microbial functional pathways. This analysis was also conducted using LEfSe, with only pathways exhibiting an LDA score >2 presented. Co-occurrence probability of protective metabolite enriched in the positive group and the featured microbial taxa in the strong (D) and weak (E) positive groups.
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References

    1. Ng SC, Peng Y, Zhang L, et al. Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events. Gut 2022;71:1106–16. 10.1136/gutjnl-2021-326563 - DOI - PMC - PubMed
    1. Lin R, Xiao M, Cao S, et al. Distinct gut microbiota and health outcomes in asymptomatic infection, viral nucleic acid test re‐positive, and convalescent COVID‐19 cases. mLife 2022;1:183–97. 10.1002/mlf2.12022 - DOI - PMC - PubMed
    1. Trompette A, Gollwitzer ES, Pattaroni C, et al. Dietary fiber confers protection against flu by shaping Ly6C- patrolling monocyte hematopoiesis and CD8+ T cell metabolism. Immunity 2018;48:992–1005. 10.1016/j.immuni.2018.04.022 - DOI - PubMed
    1. Renda G, Gökkaya İ, Şöhretoğlu D. Immunomodulatory properties of triterpenes. Phytochem Rev 2022;21:537–63. 10.1007/s11101-021-09785-x - DOI - PMC - PubMed
    1. Yi Y, Li J, Lai X, et al. Natural triterpenoids from Licorice potently inhibit SARS-CoV-2 infection. J Adv Res 2022;36:201–10. 10.1016/j.jare.2021.11.012 - DOI - PMC - PubMed

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