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Comment
. 2024 Jan;34(1):7-8.
doi: 10.1038/s41422-023-00876-2.

Chromosomal instability drives immunosuppression and metastatic dissemination

Ilio Vitale  1   2 , Claudia Galassi  3 , Lorenzo Galluzzi  4   5   6
Affiliations
Comment

Chromosomal instability drives immunosuppression and metastatic dissemination

Ilio Vitale et al. Cell Res. 2024 Jan.
No abstract available

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Figures

Fig. 1
Fig. 1. CIN drives metastatic cancer dissemination through rewiring of cGAS-STING1 signaling.
Persisting CIN in cancer cells results in a progressive reduction in the ability of micronuclei to drive productive type I IFN responses downstream of cGAS and STING1, a tachyphylactic response that involves ER stress and culminates with the establishment of an immunosuppressive (IS) TME that is permissive for disease progression in the context of metastatic dissemination. ATF6 activating transcription factor 6; CCL2 C-C motif chemokine ligand 2; CXCL1 C-X-C motif chemokine ligand 1; IRE1α (official name: ERN2) endoplasmic reticulum to nucleus signaling 2; IL11 interleukin 11; PERK (official name: EIF2AK3) eukaryotic translation initiation factor 2 alpha kinase 3.
See this image and copyright information in PMC

Comment on

  • Non-cell-autonomous cancer progression from chromosomal instability.
    Li J, Hubisz MJ, Earlie EM, Duran MA, Hong C, Varela AA, Lettera E, Deyell M, Tavora B, Havel JJ, Phyu SM, Amin AD, Budre K, Kamiya E, Cavallo JA, Garris C, Powell S, Reis-Filho JS, Wen H, Bettigole S, Khan AJ, Izar B, Parkes EE, Laughney AM, Bakhoum SF. Li J, et al. Nature. 2023 Aug;620(7976):1080-1088. doi: 10.1038/s41586-023-06464-z. Epub 2023 Aug 23. Nature. 2023. PMID: 37612508 Free PMC article.

References

    1. Bakhoum SF, Cantley LC. Cell. 2018;174:1347–1360. doi: 10.1016/j.cell.2018.08.027. - DOI - PMC - PubMed
    1. Vitale I, Shema E, Loi S, Galluzzi L. Nat. Med. 2021;27:212–224. doi: 10.1038/s41591-021-01233-9. - DOI - PubMed
    1. Janssen A, Kops GJ, Medema RH. Proc. Natl. Acad. Sci. USA. 2009;106:19108–19113. doi: 10.1073/pnas.0904343106. - DOI - PMC - PubMed
    1. Vanpouille-Box C, Demaria S, Formenti SC, Galluzzi L. Cancer Cell. 2018;34:361–378. doi: 10.1016/j.ccell.2018.05.013. - DOI - PubMed
    1. Yamazaki T, et al. Nat. Immunol. 2020;21:1160–1171. doi: 10.1038/s41590-020-0751-0. - DOI - PubMed

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