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Review
. 2023 Nov;43(8):3915-3928.
doi: 10.1007/s10571-023-01413-w. Epub 2023 Sep 22.

The Impact of Cerebral Ischemia on Antioxidant Enzymes Activity and Neuronal Damage in the Hippocampus

Jafar Sadeghzadeh  1 , Leila Hosseini  2 , Ahmad Mobed  3 , Hamid Soltani Zangbar  1 , Jaber Jafarzadeh  4 , Jamshid Pasban  1 , Parviz Shahabi  5
Affiliations
Review

The Impact of Cerebral Ischemia on Antioxidant Enzymes Activity and Neuronal Damage in the Hippocampus

Jafar Sadeghzadeh et al. Cell Mol Neurobiol. 2023 Nov.

Abstract

Cerebral ischemia and subsequent reperfusion, leading to reduced blood supply to specific brain areas, remain significant contributors to neurological damage, disability, and mortality. Among the vulnerable regions, the subcortical areas, including the hippocampus, are particularly susceptible to ischemia-induced injuries, with the extent of damage influenced by the different stages of ischemia. Neural tissue undergoes various changes and damage due to intricate biochemical reactions involving free radicals, oxidative stress, inflammatory responses, and glutamate toxicity. The consequences of these processes can result in irreversible harm. Notably, free radicals play a pivotal role in the neuropathological mechanisms following ischemia, contributing to oxidative stress. Therefore, the function of antioxidant enzymes after ischemia becomes crucial in preventing hippocampal damage caused by oxidative stress. This study explores hippocampal neuronal damage and enzymatic antioxidant activity during ischemia and reperfusion's early and late stages.

Keywords: Antioxidant enzymes; Cerebral ischemia; Hippocampus; Neuronal damage; Oxidative stress.

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Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Enzymatic antioxidant levels and hippocampal neuronal damage during early and late stages of ischemia
Fig. 2
Fig. 2
Disruption in the balance between oxidative stress production and the enzymatic antioxidant system due to cerebral ischemia and its impact on neural damage and cognitive impairment
Fig. 3
Fig. 3
Molecular ischemia mechanisms at synaptic levels and the resulting neuronal effects in early and late stages
See this image and copyright information in PMC

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