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Meta-Analysis
. 2023 Sep 22;23(1):587.
doi: 10.1186/s12877-023-04287-1.

Traumatic life events and risk for dementia: a systematic review and meta-analysis

Emilia Severs  1 , Tiffeny James  1 , Pilar Letrondo  1 , Lise Løvland  1 , Natalie L Marchant  1 , Naaheed Mukadam  2
Affiliations
Meta-Analysis

Traumatic life events and risk for dementia: a systematic review and meta-analysis

Emilia Severs et al. BMC Geriatr. .

Abstract

Objectives: To systematically review the association between traumatic life events (TLE) and dementia risk.

Design: Systematic review and meta-analysis.

Data sources: APA, PsychINFO, Embase and MEDLINE from their inception to 29.05.21 and updated on 20.04.22.

Eligibility criteria for selecting studies: Original research articles published in peer reviewed journals examining the association between TLE and all cause dementia in individuals aged 60 and over. Two researchers independently assessed the risk of bias using the Newcastle-Ottawa Scale. We conducted a generic inverse variance random effects meta-analysis to provide an overall estimate of TLE impact on dementia risk.

Main outcome measures: Risk, odds and hazards ratios relating to dementia risk.

Results: Initially, 3,487 studies were retrieved in the search and seven studies were included in the meta-analysis with data being used from 276,570 participants. TLE were associated with increased dementia risk. Trauma in general had a pooled HR of 1.21, (95% CI 1.03, 1.43, P = 0.0001). War/ Holocaust trauma and childhood trauma were also associated with increased dementia risk (HR = 1.28 (95% CI 1.01-1.63, P = 0.02) and HR = 1.76 (95% CI 1.17-2.64, P = 0.007) respectively).

Conclusions: We have found an association between TLE and dementia risk. Future research exploring the dimensions of TLE and individual level factors are needed to better understand the relationship between TLE and dementia.

Trial registration: PROSPERO CRD42021253090.

Keywords: Dementia; Risk; Traumatic life events.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram
Fig. 2
Fig. 2
Meta-analysis of all included studies
Fig. 3
Fig. 3
Funnel plot to assess publication bias
Fig. 4
Fig. 4
Meta-analysis of studies looking at war/Holocaust related trauma
Fig. 5
Fig. 5
Meta-analysis of studies looking at childhood trauma
See this image and copyright information in PMC

References

    1. Collaborators GDF. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of Disease Study 2019. The Lancet Public Health 2022. - PMC - PubMed
    1. Livingston G, Huntley J, Sommerlad A et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet 2020. - PMC - PubMed
    1. Tani Y, Fujiwara T, Kondo K. Association between adverse childhood experiences and dementia in older japanese adults. JAMA Netw Open. 2020;3(2):e1920740–e. doi: 10.1001/jamanetworkopen.2019.20740. - DOI - PubMed
    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub; 2013.
    1. Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci. 2009;10(6):434–45. doi: 10.1038/nrn2639. - DOI - PubMed

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