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. 2024 Jun 14;229(6):1812-1816.
doi: 10.1093/infdis/jiad411.

Dynamics and Clinical Significance of Cytomegalovirus-Specific Neutralizing Antibodies in Kidney Transplant Recipients Treated with T-Cell-Depleting Agents

Mario Fernández-Ruiz  1   2   3 , Estéfani García-Ríos  4   5 , Natalia Redondo  1   2 , Isabel Rodríguez-Goncer  1   2 , Tamara Ruiz-Merlo  1   2 , Patricia Parra  1   2 , Virginia Sandonis  4 , Francisco López-Medrano  1   2   3 , Rafael San Juan  1   2   3 , Esther González  3   6 , Natalia Polanco  3   6 , Amado Andrés  3   6 , David Navarro  2   7   8 , José María Aguado  1   2   3 , Pilar Pérez-Romero  4
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Dynamics and Clinical Significance of Cytomegalovirus-Specific Neutralizing Antibodies in Kidney Transplant Recipients Treated with T-Cell-Depleting Agents

Mario Fernández-Ruiz et al. J Infect Dis. .

Abstract

We measured cytomegalovirus (CMV)-specific antibodies that neutralize epithelial cell infection (CMV-AbNEIs) in 101 CMV-seropositive kidney transplant recipients (KTRs) at baseline and posttransplant months 3 and 6. All the patients received antithymocyte globulin and 3-month valganciclovir prophylaxis. There were no significant differences in pretransplant AbNEIs titers between KTRs that developed or did not develop any-level CMV infection or the composite of high-level infection and/or disease. One-year CMV infection-free survival was comparable between KTRs with or without pretransplant CMV-AbNEIs. No differences were observed by months 3 and 6. We observed no protective role for CMV-AbNEIs among CMV-seropositive KTRs undergoing T-cell-depleting induction.

Keywords: T-cell–mediated immunity; antibodies neutralizing virus epithelial infection; antithymocyte globulin; cytomegalovirus; humoral immunity; kidney transplantation.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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