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. 2023 Dec;149(19):16983-16992.
doi: 10.1007/s00432-023-05397-4. Epub 2023 Sep 23.

Evaluation of survival outcome and prognostic factors for oral cavity cancer treated with volumetric arc therapy

Himanshu Mishra  1 , Shreya Singh  1 , Ritusha Mishra  2 , Ankita Pandey  3 , Abhijit Mandal  1 , Ekta Prakash  1 , Ganeshkumar Patel  1 , Manav Shah  1 , Tej Bali Singh  4
Affiliations

Evaluation of survival outcome and prognostic factors for oral cavity cancer treated with volumetric arc therapy

Himanshu Mishra et al. J Cancer Res Clin Oncol. 2023 Dec.

Abstract

Purpose: This study aimed to evaluate the survival outcomes and identify prognostic factors for patients with oral cavity cancer (OCC) who underwent adjuvant treatment with volumetric arc therapy (VMAT) using simultaneous integrated boost (SIB).

Methods: Data was collected for post-operated patients of carcinoma of oral cavity who received adjuvant VMAT with SIB between June 2018 and December 2022. The data was entered and analyzed using SPSS software version 20.0. Survival rates were estimated using Kaplan Meier method. To determine survival difference between the groups, log rank test was used. Multivariate analyses were performed with Cox proportional hazard model and p value < 0.05 was considered as significant.

Results: A total of 178 patients were included in the study. The median follow-up period was 26 months (range 3-56 months). The 3-year OS, DFS, and LRC rates were 78% (95% CI 77-79%), 76% (95% CI 74-77%), and 81% (95% CI 80-82%), respectively. Univariate analysis identified age ≥ 50 years, lymph node involvement, extracapsular extension (ECE), and N2-N3 disease as significant adverse prognostic factors for OS, DFS, and LRC. Multivariate analysis confirmed age ≥ 50 years and nodal involvement as independent predictors of worse OS, DFS, and LRC. Additionally, ECE independently affected OS and DFS.

Conclusion: Adjuvant treatment with VMAT using SIBin patients with OCC is effective. Age and nodal involvement had significant impact on LRC, DFSand OS while ECE on DFSand OS.

Keywords: Oral cavity; Prognostic factors; Squamous cell carcinoma; Survival; Volumetric-modulated arc therapy.

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Conflict of interest statement

The author(s) declare no competing interests.

Figures

Fig. 1
Fig. 1
a–c Kaplan–Meier graph for overall survival, disease free survival and loco-regional control of the study population, respectively
Fig. 2
Fig. 2
a–c Effect of age, nodal involvement and ECE on overall survival
Fig. 3
Fig. 3
a–c Effect of age, nodal involvement and ECE on disease-free survival
Fig. 4
Fig. 4
a, b Effect of age and nodal involvement on loco-regional control
See this image and copyright information in PMC

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