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Review
. 2023 Nov;22(11):103453.
doi: 10.1016/j.autrev.2023.103453. Epub 2023 Sep 21.

Roles of interferon induced protein with tetratricopeptide repeats (IFIT) family in autoimmune disease

Yuan-Yuan Wu  1 , Jun Xing  2 , Xiao-Feng Li  3 , Ying-Li Yang  3 , Hua Shao  4 , Jun Li  5
Affiliations
Review

Roles of interferon induced protein with tetratricopeptide repeats (IFIT) family in autoimmune disease

Yuan-Yuan Wu et al. Autoimmun Rev. 2023 Nov.

Abstract

Interferon-induced tetrapeptide repeat (IFIT) family proteins are an important component of the antiviral immune response. There are four known members of the human IFIT family, namely IFIT1, IFIT2, IFIT3 and IFIT5. More and more evidence shows that IFIT family members are involved in a variety of pathophysiological processes in vivo, regulate the homeostasis and differentiation of a variety of cells including immune cells, and are closely related to a variety of autoimmune diseases, which is expected to become a new therapeutic target. This review reviews the biological roles of different IFIT proteins in various autoimmune diseases, and highlights the potential use of these molecules as biomarkers and prognostic factors in autoimmune diseases, with a view to providing ideas for exploring the diagnosis and treatment of autoimmune diseases.

Keywords: Autoimmune disease; Diagnostics; IFIT family; IFN-I signaling pathway; Treatment.

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Conflict of interest statement

Declaration of Competing Interest The authors declared that they have no conflicts of interest to this work.We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.

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