Novel approaches to functional lateralization: Assessing information in activity patterns across hemispheres and more accurately identifying structural homologues

Abstract

Functional lateralization is typically measured by comparing activation levels across the right and left hemispheres of the brain. Significant additional information, however, exists within distributed multi-voxel patterns of activity - a format not detectable by traditional activation-based analysis of functional magnetic resonance imaging (fMRI) data. We introduce and test two methods -one anatomical, one functional- that allow hemispheric information asymmetries to be detected. We first introduce and apply a novel tool that draws on brain 'surface fingerprints' to pair every location in one hemisphere with its hemispheric homologue. We use anatomical data to show that this approach is more accurate than the common distance-from-midline method for comparing bilateral regions. Next, we introduce a complementary analysis method that quantifies multivariate laterality in functional data. This new 'multivariate Laterality Index' (mLI) reflects both quantitative and qualitative information-differences across homologous activity patterns. We apply the technique here to functional data collected as participants viewed faces and non-faces. Using the previously generated surface fingerprints to pair-up homologous searchlights in each hemisphere, we use the novel multivariate laterality technique to identify face-information asymmetries across right and left counterparts of the fusiform gyrus, inferior temporal gyrus, superior parietal lobule, and early visual areas. The typical location of the fusiform face area has greater information asymmetry for faces than for shapes. More generally, we argue that the field should consider an information-based approach to lateralization.