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Meta-Analysis
. 2023 Nov;31(4):605-611.
doi: 10.1016/j.mric.2023.06.006. Epub 2023 Aug 3.

Systematic Review and Metanalysis on the Role of Prostate-Specific Membrane Antigen Positron Emission Tomography/Magnetic Resonance Imaging for Intraprostatic Tumour Assessment

Paola Mapelli  1 , Samuele Ghezzo  1 , Alessandro Spataro  2 , Carolina Bezzi  1 , Ana Maria Samanes Gajate  3 , Arturo Chiti  1 , Maria Picchio  4
Affiliations
Meta-Analysis

Systematic Review and Metanalysis on the Role of Prostate-Specific Membrane Antigen Positron Emission Tomography/Magnetic Resonance Imaging for Intraprostatic Tumour Assessment

Paola Mapelli et al. Magn Reson Imaging Clin N Am. 2023 Nov.

Abstract

The present systematic review and meta-analysis are focused on the diagnostic accuracy of PSMA PET/MRI in primary prostate cancer assessment. A literature search was conducted on the PubMed database using the terms "PSMA" AND "prostate cancer" or "prostate" AND "PET/MRI" or "PET MRI" or "PET-MRI" or "PET-MR" AND "primary" or "staging." Ten articles were eligible for analysis after applying the exclusion criteria. PET/MRI showed better diagnostic accuracy in detecting primary PCa compared to multiparametric (mp) MRI and PET alone. The pooled sensitivity and specificity of 68Ga-PSMA PET/MRI at the per-patient level were 0.976 (CI: 0.943-0.991) and 0.739 (CI: 0.437-0.912); respectively. PSMA PET/MRI has good sensitivity in detecting primary PCa, especially in patients with PIRADS 3 PCa.

Keywords: (18)F-DCFPyL; (18)F-PSMA-1007; (68)Ga-PSMA; Accuracy; PET/MRI; Primary; Prostate cancer; Staging.

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