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. 2023 Nov 12:681:1-6.
doi: 10.1016/j.bbrc.2023.09.040. Epub 2023 Sep 19.

BMP-2-mediated signaling suppresses salivary gland development

Shinnosuke Ono  1 , Atsushi Yamada  2 , Junichi Tanaka  3 , Akane Yukimori  3 , Kiyohito Sasa  4 , Kenji Mishima  3 , Takahiro Funatsu  5 , Ryutaro Kamijo  4
Affiliations

BMP-2-mediated signaling suppresses salivary gland development

Shinnosuke Ono et al. Biochem Biophys Res Commun. .

Abstract

Research regarding the process of salivary gland development and elucidation of related mechanisms are considered essential for development of effective treatments for conditions associated with salivary disease. Various reports regarding the effects of bone morphogenetic protein (BMP)-2 on hard tissue cells have been presented, though few have examined those related to salivary gland formation. Using an organ culture system, the present study was conducted to investigate the function of BMP-2 in salivary gland formation. Salivary glands obtained from embryonic day 13.5 mice and treated with BMP-2 showed suppression of primordial cell differentiation and also gland formation in a concentration-dependent manner. Furthermore, gland formation inhibition was suppressed by concurrent treatment with dorsomorphin, an inhibitor of the Smad pathway. Expression levels of AQP5, a marker gene for acinar cells, and Prol1, an opiorphin expressed in the lacrimal gland, were decreased in salivary glands treated with BMP-2. The present findings indicate that suppression of salivary gland formation, especially acinar differentiation, is induced by BMP-2, a phenomenon considered to be related to the Smad pathway.

Keywords: BMP-2; SMAD; Salivary gland.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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