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. 2023 Oct:83:102785.
doi: 10.1016/j.anaerobe.2023.102785. Epub 2023 Sep 23.

Upregulation of the cfiA carbapenemase gene in a Bacteroides fragilis strain by the novel integrative and conjugative element Tn7563

Tore Taksdal Stubhaug  1 , Nermin Zecic  2 , Dagfinn Skaare  2
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Free article

Upregulation of the cfiA carbapenemase gene in a Bacteroides fragilis strain by the novel integrative and conjugative element Tn7563

Tore Taksdal Stubhaug et al. Anaerobe. 2023 Oct.
Free article

Abstract

We describe Tn7563, a 31,844-bp integrative and conjugative element (ICE) carrying promoters upregulating the cfiA carbapenemase gene in Bacteroides fragilis strain Tbg-22. Excision and circularization of Tn7563 was demonstrated by PCR. Previously, only insertion sequences (IS) have been shown to carry mobile promoters for cfiA.

Keywords: Bacteroides; Carbapenemase; Gene expression; Integrative and conjugative elements.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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