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. 2023 Dec;39(12):892-894.
doi: 10.1016/j.tig.2023.09.005. Epub 2023 Sep 22.

Protecting axons in grandchildren

Surojit Sural  1
Affiliations

Protecting axons in grandchildren

Surojit Sural. Trends Genet. 2023 Dec.

Abstract

Prenatal exposure to environmental agents can influence the fitness of not only the fetus, but also subsequent generations. In a recent study, Wang et al. demonstrated that feeding ursolic acid (UA), a plant-derived compound, to Caenorhabditis elegans mothers during their reproductive period prevented neurodegeneration in not only their offspring, but also the F2 progeny.

Keywords: C. elegans; axon degeneration; intergenerational; neuroprotection; non-Mendelian; sphingolipid.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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