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Editorial
. 2023 Sep 7:14:1278677.
doi: 10.3389/fimmu.2023.1278677. eCollection 2023.

Editorial: Translation of genetically engineered T cells in cancer immunotherapy

Ralf-Holger Voss  1 , Hakim Echchannaoui  2   3   4 , He Huang  5 , Shao-An Xue  6   7
Affiliations
Editorial

Editorial: Translation of genetically engineered T cells in cancer immunotherapy

Ralf-Holger Voss et al. Front Immunol. .
No abstract available

Keywords: CAR toxicity; CAR-T; TCR-T; cancer immunotherapy; genetic/cellular engineering; genome editing; immunosuppression; tumor specific/associated antigens.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Apple pie chart attributing 11 articles (2 reviews, 8 original research articles, 1 case report) to the 6 topics 1.-6. listed in the Editorial summary in a clockwise manner. The 11 articles are indicated by their first author names. The 6 apple pie pieces are colour-coded according to their assigned articles covering either the subject TCR (red), CAR (blue), or both (purple). The review articles are shown in the center of the chart indicating to which topics they refer to. TCRs, CARs, MHCs, PD-1, IL-12, and GABs are depicted in a stylised fashion. The outline of the circle represents the T-cell membrane where all immunoreceptors (TCRs, CARs) are embedded. IL-12, GABs and MHCs are either soluble molecules or membrane proteins from target cells, respectively, and hence located outside the circle. Tumor antigens presented by MHC are indicated as coloured spheres, depending on the particular peptide. Antigen specificities of TCRs, CARs and GABs are denoted besides the stylised molecule. Helical DNA, lentivirus, recombinant transposon DNA, and colon are adumbrated as cell or body internal components and hence, located inside the circle. Red double/single arrows represent mutually interacting/inflammatory, a ‘┴’ inhibitory reactions, a blue arrow an activating reaction in transcription/translation, green lines in a TCR denotes point mutations in TCR Vβ domain. Abbreviations: TSA tumor specific antigen, TAA tumor associated antigen, TCR T-cell receptor, CAR chimeric antigen receptor, GAB gamma delta TCR anti-CD3 bispecific molecule, CMV cytomegalovirus, allo alloreactive, IL-12 interleukin 12, KO knock out, KI knock in, CRISPR clustered regularly interspaced short palindromic repeats, PD-1 programmed cell death protein 1, LV lentivirus, PB PiggyBac, IR inverted repeats, GOI gene of interest, Rac1P29S, PRAME, CTCFL, Her2, CEA, CMV, HA1, NY-ESO-1, CD19 represent processed or full length tumor/viral antigens, respectively.
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  • Editorial on the Research Topic Translation of genetically engineered T cells in cancer immunotherapy

References

    1. Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, et al. . T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med (2011) 3(95):95ra73. doi: 10.1126/scitranslmed.3002842 - DOI - PMC - PubMed
    1. Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, et al. . Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. New Engl J Med (2013) 368(16):1509–18. doi: 10.1056/NEJMoa1215134 - DOI - PMC - PubMed
    1. Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, et al. . Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. New Engl J Med (2018) 378(5):439–48. doi: 10.1056/NEJMoa1709866 - DOI - PMC - PubMed
    1. Boyiadzis MM, Dhodapkar MV, Brentjens RJ, Kochenderfer JN, Neelapu SS, Maus MV, et al. . Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic Malignancies: clinical perspective and significance. J Immunother Cancer (2018) 6(1):137. doi: 10.1186/s40425-018-0460-5 - DOI - PMC - PubMed
    1. Ruella M, Maus MV. Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies. Comput Struct Biotechnol J (2016) 14:357–62. doi: 10.1016/j.csbj.2016.09.003 - DOI - PMC - PubMed

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