Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 27:27:100216.
doi: 10.1016/j.tipsro.2023.100216. eCollection 2023 Sep.

Investigating the feasibility of using Ethos generated treatment plans for head and neck cancer patients

Adam El-Qmache  1 , John McLellan  1
Affiliations

Investigating the feasibility of using Ethos generated treatment plans for head and neck cancer patients

Adam El-Qmache et al. Tech Innov Patient Support Radiat Oncol. .

Abstract

The Varian Ethos treatment platform is designed to automatically create complex RT treatment plans, reducing both workload and operator variability in plan quality. The aim of this study is to evaluate the quality of Ethos-generated head and neck (H&N) treatment plans. Ethos plans were created for ten previous H&N patients and these were compared with the original clinical plans generated in Eclipse. Ethos automatically creates several plans with different field arrangements for each patient. All plans were compared quantitatively using: dose-volume metrics; dose conformity; dose heterogeneity and monitor units (MU). In addition, two H&N Oncologists assessed the clinical acceptability of the Ethos plans. Consultant 1 judged there to be at least three clinically acceptable Ethos plans for 9 out of 10 patients reviewed. Consultant 2 approved of at least two Ethos plans for 5 out of 5 patients reviewed. The Ethos plans' average dose metrics were comparable to the clinical plans. The average plan MU was similar for Eclipse and Ethos VMAT plans. The average plan MU for Ethos IMRT plans was larger with respect to all VMAT plans. The Ethos Treatment Planning system is capable of automatically creating good quality treatment plans for a range of H&N cancer patients.

Keywords: Ethos; H&N cancer; IMRT; Intelligent optimisation engine; Treatment planning.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Ethos plan evaluation example. Patient 10 (Larynx) 9-field IMRT plan (RHS) being assessed next to reference Eclipse plan. PTVLD (54 Gy in 30 #) shown in both plans. Doses of 57 Gy and above displayed.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Varian. Ethos Algorithms Reference Guide.: Publication ID:P1035867-330C; 2019.
    1. Byrne M., Archibald-Heeren B., Hu Y., Teh A., Beserminji R., Cai E., et al. Varian ethos online adaptive radiotherapy for prostate cancer: Early results of contouring accuracy, treatment plan quality, and treatment time. J Appl Clin Med Phys. 2022;23(1):e13479. - PMC - PubMed
    1. Lim-Reinders S., Keller B.M., Al-Ward S., Sahgal A., Kim A. Online adaptive radiation therapy. Int J Radiat Oncol Biol Phys. 2017;99(4):994–1003. - PubMed
    1. Archambault Y., Boylan C., Bullock D., Morgas T., Peltola J., Ruokokoski E., et al. Making on-line adaptive radiotherapy possible using artificial intelligence and machine learning for efficient daily re-planning. Med Phys Intl J. 2020;8(2)
    1. Pokharel S., Pacheco A., Tanner S. Assessment of efficacy in automated plan generation for Varian Ethos intelligent optimization engine. J Appl Clin Med Phys. 2022;23(4):e13539. - PMC - PubMed