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Clinical Trial
. 1979 May;18(2):114-8.
doi: 10.1093/rheumatology/18.2.114.

A double-blind cross-over evaluation of ketoprofen (Orudis) and ibuprofen in the management of rheumatoid arthritis

F Montrone, M Fumagalli, P Pellegrini, G Ratti, G Sala, C Liverta, C Pollini, A E Pontiroli
Clinical Trial

A double-blind cross-over evaluation of ketoprofen (Orudis) and ibuprofen in the management of rheumatoid arthritis

F Montrone et al. Rheumatol Rehabil. 1979 May.

Abstract

In a multi-centre double-blind cross-over trial using the double-placebo technique, 55 patients with rheumatoid arthritis were treated for 10 days for each trial drug with ketoprofen (200 mg/day) and ibuprofen (1200 mg/day). Both drugs induced a clinically and statistically significant improvement of all the symptoms studied, except for pain at night during ibuprofen administration. Ketoprofen displayed a therapeutic efficacy significantly superior to ibuprofen in five of the eight symptoms studied. Side-effects were recorded in 10 patients receiving ketoprofen (one patient withdrew because of heartburn) and in nine patients receiving ibuprofen.

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