Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep 6:10:1197427.
doi: 10.3389/fcvm.2023.1197427. eCollection 2023.

Progressive alterations of left atrial and ventricular volume and strain across chronic kidney disease stages: a speckle tracking echocardiography study

Hoai Thi Thu Nguyen  1   2 , Chien Van Do  3 , Dieu Thi Vu Dang  1 , Loi Doan Do  1   4 , Linh Huu Doan  1   2 , Ha Thi Viet Dang  5   6
Affiliations

Progressive alterations of left atrial and ventricular volume and strain across chronic kidney disease stages: a speckle tracking echocardiography study

Hoai Thi Thu Nguyen et al. Front Cardiovasc Med. .

Abstract

Background: It has been a scarcity of evidence regarding differences in left ventricular (LV) and left atrial (LA) size and strain changes across stages of chronic kidney disease (CKD) and which echocardiographic parameters could be utilized to predict the decline of glomerular filtration rate (GFR).

Objectives: This study aimed to evaluate the alterations of LV and LA strain across the reduction of renal function and potential echocardiographic parameters which could be correlated with the GFR decline among patients with CKD.

Method: A cross-sectional study was conducted on 169 CKD patients at Bach Mai General Hospital, Hanoi, Vietnam from April to November 2022. Demographic, clinical and laboratory characteristics of patients were collected. Transthoracic echocardiography was performed to measure LV and LA size and strains. Jonckheere-Terpstra test was used to measure the tendency of change. Multivariate linear regression models were performed to find associations between different echocardiographic parameters and renal function reduction.

Results: The number of patients with CKD stages 1, 2, 3, 4, and 5 was 21 (12.4%), 28 (16.6%), 27 (16.0%), 22 (13.0%) and 71 (42.0%), respectively. CKD severity was positively associated with LV diastolic and systolic diameters, LV mass, E/e' ratio, and maximal tricuspid regurgitation velocity (TR max), and negatively correlated with the LV global longitudinal strain. Higher severity of CKD stage was associated with higher LA diameter, LA strain, and volume in four and two-chamber views, and lower LA reservoir and conduit function. Left ventricular mass (β = 0.068), ejection fraction (β = 0.112) and left atrial reservoir (β = -0.077) were associated with reduced GFR.

Conclusion: Left ventricular mass, ejection fraction, and atrial longitudinal strain by STE should be done at the earlier stages of CKD patients for better follow-up of GFR decline.

Keywords: cardiovascular disease; chronic kidney disease; left atrial strain; left ventricular strain; speckle tracking echocardiography.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Measurement of left atrial volume (LAVI) and strain (LASr).
Figure 2
Figure 2
Left atrial volume index (LAVi), left atrial phasic strains reservoir phase (LASr), left atrial phasic strains conduit phase (LAScd), global longitudinal strain (GLS) across CKD stages 1–5.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl. (2022) 12(1):7–11. 10.1016/j.kisu.2021.11.003 - DOI - PMC - PubMed
    1. Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. (2010) 375(9731):2073–81. 10.1016/S0140-6736(10)60674-5 - DOI - PMC - PubMed
    1. Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. (2011) 80(12):1258–70. 10.1038/ki.2011.368 - DOI - PubMed
    1. Paoletti E, Zoccali C. A look at the upper heart chamber: the left atrium in chronic kidney disease. Nephrol Dial Transplant. (2013) 29(10):1847–53. 10.1093/ndt/gft482 - DOI - PubMed
    1. Hensen LCR, Goossens K, Delgado V, Rotmans JI, Jukema JW, Bax JJ. Prognostic implications of left ventricular global longitudinal strain in predialysis and dialysis patients. Am J Cardiol. (2017) 120(3):500–4. 10.1016/j.amjcard.2017.04.054 - DOI - PubMed