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. 2022 Aug 18;1(2):e00011.
doi: 10.1097/PN9.0000000000000011. eCollection 2022 Sep.

Boston Birth Cohort profile: rationale and study design

Colleen Pearson  1 , Tami Bartell  2 , Guoying Wang  3 , Xiumei Hong  3 , Serena A Rusk  3 , LingLing Fu  1 , Sandra Cerda  4 , Blandine Bustamante-Helfrich  5 , Wendy Kuohung  6 , Christina Yarrington  6 , William G Adams  1 , Xiaobin Wang  3   7
Affiliations

Boston Birth Cohort profile: rationale and study design

Colleen Pearson et al. Precis Nutr. .

Abstract

In1998, the Boston Birth Cohort (BBC) was initiated at Boston Medical Center (BMC) in response to persistently high rates of preterm birth (PTB, defined as birth before 37 weeks of gestation) in the US population and the longstanding profound PTB disparity among Black, Indigenous, and people of color (BIPOC). The BBC encompasses two linked study protocols: The PTB Study serves as the baseline recruitment in the BBC. It aims to address fundamental questions about the causes and consequences of PTB. The study oversamples preterm babies using a case/control study design, in which cases are defined as mothers who deliver a preterm and/or low birthweight baby (<2500 grams regardless of gestational age). Controls are enrolled at a 2:1 control/case ratio and matched by maternal age (±5 years), self-reported race and ethnicity, and date of delivery (± 7 days for case delivery). From inception, it was designed as a comprehensive gene-environmental study of PTB. As a natural extension, the Children's Health Study, under a separate but linked Institutional Review Board protocol, is a longitudinal follow-up study of the participants who were recruited at birth in the PTB Study and who continue pediatric care at BMC. This linked model allows for investigation of early life origins of pediatric and chronic disease in a prospective cohort design. The BBC is one of the largest and longest National Institutes of Health-funded prospective birth cohort studies in the United States, consisting of 8733 mother-child dyads enrolled in the PTB Study at birth, and of those, 3592 children have been enrolled in the Children's Health Study, with a median follow-up of 14.5 years. The BBC mirrors the urban, underresourced, and underrepresented BIPOC population served by BMC. A high proportion of BBC children were born prematurely and had chronic health conditions (e.g., asthma, obesity, and elevated blood pressure) in childhood. The BBC's long-term goal has been to build a large, comprehensive database (epidemiological, clinical, and multiomics) and biospecimen repository to elucidate early life origins of pediatric and chronic diseases and identify modifiable upstream factors (e.g., psychosocial, environmental, and nutritional) to improve health across the life course for BIPOC mothers and children.

Keywords: Boston Birth Cohort; Early life origins of chronic diseases; Environment; Genetics; Longitudinal study.

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Conflict of interest statement

None declared.

Figures

Figure 1.
Figure 1.
Early conceptual framework for studying preterm birth pathways in the BBC. Adapted from Wang et al [48]. BBC, Boston Birth Cohort; HPA, hypothalamus pituitary adrenal gland; PROM, premature rupture of membranes.
Figure 2.
Figure 2.
Illustration of the Boston Birth Cohort with two linked IRB-approved protocols at the Boston Medical Center. IRB, Institutional Review Board.
Figure 3.
Figure 3.
Updated conceptual framework for studying PTB pathways in the BBC. BBC, Boston Birth Cohort; PTB, preterm birth.
See this image and copyright information in PMC

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