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Case Reports
. 2023 Sep 4;19(4):75.
doi: 10.3892/br.2023.1657. eCollection 2023 Oct.

Gastric metastasis in patients with leiomyosarcoma: A case report

Teruya Uchiyama  1 , Tomoki Nakamura  1 , Kenta Nakata  1 , Ryohei Adachi  1 , Tomohito Hagi  1 , Kunihiro Asanuma  1 , Akihiro Sudo  1
Affiliations
Case Reports

Gastric metastasis in patients with leiomyosarcoma: A case report

Teruya Uchiyama et al. Biomed Rep. .

Abstract

Soft tissue sarcomas (STS) are very rare tumors, accounting for <1% of all malignancies. Leiomyosarcoma (LMS), accounts for 10-20% of STS. Gastric metastasis of LMS is extremely rare, and only a few cases have been reported. In the present report, two clinical cases of LMS with gastric metastasis. In the present cases, the metastases presented as a solitary lesion and was located in the upper body anterior wall in case 1, and body-greater curvature in case 2. It is debatable whether to perform any local treatment for gastric metastasis due to its poor prognosis. However, the progression of metastatic cancer in the stomach can lead to gastric bleeding, abdominal pain, and dysphagia, which may further shorten survival and decrease a patient's quality of life. Therefore, metastasectomy was performed in the present cases. This should be considered if digestive tract symptoms occur during the treatment of LMS.

Keywords: gastric metastasis; leiomyosarcoma; metastasectomy; prognosis; soft tissue sarcoma.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Computed tomography showing a 5 cm mass in the thigh (A) Axial view and (B) coronal view (Case 1).
Figure 2
Figure 2
Microscopic findings showing the proliferation of spindle cells with pleomorphic nuclei (Case 1). H&E staining (A) magnification, x10; and (B) magnification, x20 of the primary site. (C) H&E staining of the stomach leiomyosarcoma; magnification, x10.
Figure 3
Figure 3
Immunohistochemical staining showing positive expression of (A) α-smooth muscle actin, (B) HHF35, (C) desmin and (D) S-100. Magnification, x20 (Case 1).
Figure 4
Figure 4
Gastroscopy showing a submucosal tumor with central erosion in the anterior upper body of the stomach (Case 2).
Figure 5
Figure 5
Computed tomography scan showing a pancreatic mass (arrow) (Case 2).
Figure 6
Figure 6
Magnetic resonance imaging showing a 6 cm mass around the proximal left fibula (A) T1 signal intensity; (B) T2 signal intensity (Case 2).
Figure 7
Figure 7
Microscopic findings showing polymorphous spindle cell proliferation at the primary site (Case 2). H&E staining (A) magnification, x10; and (B) magnification, x20 of the primary site. (C) H&E staining of the stomach leiomyosarcoma; magnification, x10.
Figure 8
Figure 8
Immunohistochemical staining showing positive expression of (A) α-smooth muscle actin, (B) caldesmon and (C) desmin, and (D) negative expression of C 56, (E) pan CK and (F) S-100; magnification, x20 (Case 2).
Figure 9
Figure 9
(A) Computed tomography scan showing a protruding mass in the upper part of the stomach (arrow). (B) FDG-positron emission tomography showing FDG uptake in the stomach (arrow), and pericardial metastasis (Case 2).
Figure 10
Figure 10
Gastroscopy showing a submucosal tumor in the anastomotic site of Billroth I, which was spreading to the jejunum (Case 2).
See this image and copyright information in PMC

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