Consensus-Based Development of a Global Registry for Traumatic Brain Injury: Establishment, Protocol, and Implementation

Alexis J Joannides¹, Tommi K Korhonen^{1

2}, David Clark¹, Sujit Gnanakumar¹, Sara Venturini¹, Midhun Mohan¹, Thomas Bashford^{1

3

4}, Ronnie Baticulon⁵, Indira Devi Bhagavatula⁶, Ignatius Esene⁷, Rocío Fernández-Méndez¹, Anthony Figaji⁸, Deepak Gupta⁹, Tariq Khan¹⁰, Tsegazeab Laeke¹¹, Michael Martin^{12

13}, David Menon³, Wellingson Paiva¹⁴, Kee B Park¹⁵, Jogi V Pattisapu^{16

17}, Andres M Rubiano¹⁸, Vijaya Sekhar^{17

19}, Hamisi K Shabani²⁰, Kachinga Sichizya²¹, Davi Solla¹⁴, Abenezer Tirsit¹¹, Manjul Tripathi²², Carole Turner¹, Bart Depreitere²³, Corrado Iaccarino^{24

25

26}, Laura Lippa²⁷, Andrew Reisner²⁸, Gail Rosseau^{29

30}, Franco Servadei³¹, Rikin A Trivedi¹, Vicknes Waran³², Angelos Kolias¹, Peter Hutchinson¹; GEO-TBI collaborative and the NIHR Global Health Research Group on Acquired Brain and Spine Injury

Affiliations

¹ NIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge , Cambridgeshire , UK.
² Neurocenter, Neurosurgery, Oulu University Hospital & University of Oulu, Oulu , Finland.
³ Division of Anaesthesia, Department of Medicine, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge , Cambridgeshire , UK.
⁴ Health Systems Design Group, Department of Engineering, University of Cambridge, Cambridge , UK.
⁵ Division of Neurosurgery, Department of Neurosciences, Philippine General Hospital & University of the Philippines Manila, Manila , Philippines.
⁶ Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, NIMHANS, Bengaluru , Karnataka , India.
⁷ Division of Neurosurgery, Faculty of Health Sciences, The University of Bamenda, Bambili , Cameroon.
⁸ Division of Neurosurgery, Neurosciences Institute, University of Cape Town, Cape Town , South Africa.
⁹ Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi , India.
¹⁰ Department of Neurosurgery, North Western General and Research Hospital, Peshawar , Pakistan.
¹¹ Division of Neurosurgery, Department of Surgery, College of Health Sciences, Addis Ababa University, Addis Ababa , Ethiopia.
¹² Orion MedTech Ltd. CIC, Cambridge , Cambridgeshire , UK.
¹³ Obex Technologies Ltd., Cambridge , Cambridgeshire , UK.
¹⁴ Division of Neurosurgery, Department of Neurology, School of Medicine, University of São Paulo, São Paulo , Brazil.
¹⁵ Department of Global Health and Social Medicine, Global Neurosurgery Initiative-Program in Global Surgery and Social Change, Harvard Medical School, Boston , Massachusetts , USA.
¹⁶ University of Central Florida College of Medicine, Orlando , Florida , USA.
¹⁷ Department of Neurosurgery, King George Hospital, Visakhapatnam , Andhra Pradesh , India.
¹⁸ Neurosciences Institute, El Bosque University, Bogotá , Colombia.
¹⁹ Current Affiliation: Department of Neurosurgery, Government General Hospital & Rangaraya Medical College, Kakinada , Andhra Pradesh , India.
²⁰ Department of Neurosurgery, Muhimbili Orthopaedic Institute, Dar es Salaam , Tanzania.
²¹ Department of Neurosurgery, University Teaching Hospital, Lusaka , Zambia.
²² Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh , India.
²³ Neurosurgery, University Hospitals Leuven, Leuven , Belgium.
²⁴ Department of Biomedical, Metabolic and Neural Sciences, School of Neurosurgery, University of Modena and Reggio Emilia, Modena , Italy.
²⁵ Division of Neurosurgery, University Hospital of Modena, Modena , Italy.
²⁶ Emergency Neurosurgery Unit, AUSL RE IRCCS, Reggio Emilia , Italy.
²⁷ Department of Neurosurgery, Ospedale Niguarda, Milan , Italy.
²⁸ Departments of Neurosurgery and Pediatrics, Children's Healthcare of Atlanta & Emory University School of Medicine, Atlanta , Georgia , USA.
²⁹ Barrow Global, Barrow Neurological Institute, Phoenix , Arizona , USA.
³⁰ Department of Neurosurgery, George Washington University School of Medicine and Health Sciences, Washington , District of Columbia , USA.
³¹ Humanitas Research Hospital-IRCCS & Humanitas University, Rozzano, Milan , Italy.
³² Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur , Malaysia.

PMID: 37747225
DOI: 10.1227/neu.0000000000002661

Consensus-Based Development of a Global Registry for Traumatic Brain Injury: Establishment, Protocol, and Implementation

Alexis J Joannides et al. Neurosurgery. 2024.

. 2024 Feb 1;94(2):278-288.

doi: 10.1227/neu.0000000000002661. Epub 2023 Sep 25.

Authors

Affiliations

¹ NIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge , Cambridgeshire , UK.
² Neurocenter, Neurosurgery, Oulu University Hospital & University of Oulu, Oulu , Finland.
³ Division of Anaesthesia, Department of Medicine, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge , Cambridgeshire , UK.
⁴ Health Systems Design Group, Department of Engineering, University of Cambridge, Cambridge , UK.
⁵ Division of Neurosurgery, Department of Neurosciences, Philippine General Hospital & University of the Philippines Manila, Manila , Philippines.
⁶ Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, NIMHANS, Bengaluru , Karnataka , India.
⁷ Division of Neurosurgery, Faculty of Health Sciences, The University of Bamenda, Bambili , Cameroon.
⁸ Division of Neurosurgery, Neurosciences Institute, University of Cape Town, Cape Town , South Africa.
⁹ Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi , India.
¹⁰ Department of Neurosurgery, North Western General and Research Hospital, Peshawar , Pakistan.
¹¹ Division of Neurosurgery, Department of Surgery, College of Health Sciences, Addis Ababa University, Addis Ababa , Ethiopia.
¹² Orion MedTech Ltd. CIC, Cambridge , Cambridgeshire , UK.
¹³ Obex Technologies Ltd., Cambridge , Cambridgeshire , UK.
¹⁴ Division of Neurosurgery, Department of Neurology, School of Medicine, University of São Paulo, São Paulo , Brazil.
¹⁵ Department of Global Health and Social Medicine, Global Neurosurgery Initiative-Program in Global Surgery and Social Change, Harvard Medical School, Boston , Massachusetts , USA.
¹⁶ University of Central Florida College of Medicine, Orlando , Florida , USA.
¹⁷ Department of Neurosurgery, King George Hospital, Visakhapatnam , Andhra Pradesh , India.
¹⁸ Neurosciences Institute, El Bosque University, Bogotá , Colombia.
¹⁹ Current Affiliation: Department of Neurosurgery, Government General Hospital & Rangaraya Medical College, Kakinada , Andhra Pradesh , India.
²⁰ Department of Neurosurgery, Muhimbili Orthopaedic Institute, Dar es Salaam , Tanzania.
²¹ Department of Neurosurgery, University Teaching Hospital, Lusaka , Zambia.
²² Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh , India.
²³ Neurosurgery, University Hospitals Leuven, Leuven , Belgium.
²⁴ Department of Biomedical, Metabolic and Neural Sciences, School of Neurosurgery, University of Modena and Reggio Emilia, Modena , Italy.
²⁵ Division of Neurosurgery, University Hospital of Modena, Modena , Italy.
²⁶ Emergency Neurosurgery Unit, AUSL RE IRCCS, Reggio Emilia , Italy.
²⁷ Department of Neurosurgery, Ospedale Niguarda, Milan , Italy.
²⁸ Departments of Neurosurgery and Pediatrics, Children's Healthcare of Atlanta & Emory University School of Medicine, Atlanta , Georgia , USA.
²⁹ Barrow Global, Barrow Neurological Institute, Phoenix , Arizona , USA.
³⁰ Department of Neurosurgery, George Washington University School of Medicine and Health Sciences, Washington , District of Columbia , USA.
³¹ Humanitas Research Hospital-IRCCS & Humanitas University, Rozzano, Milan , Italy.
³² Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur , Malaysia.

PMID: 37747225
DOI: 10.1227/neu.0000000000002661

Abstract

Background and objectives: Global disparity exists in the demographics, pathology, management, and outcomes of surgically treated traumatic brain injury (TBI). However, the factors underlying these differences, including intervention effectiveness, remain unclear. Establishing a more accurate global picture of the burden of TBI represents a challenging task requiring systematic and ongoing data collection of patients with TBI across all management modalities. The objective of this study was to establish a global registry that would enable local service benchmarking against a global standard, identification of unmet need in TBI management, and its evidence-based prioritization in policymaking.

Methods: The registry was developed in an iterative consensus-based manner by a panel of neurotrauma professionals. Proposed registry objectives, structure, and data points were established in 2 international multidisciplinary neurotrauma meetings, after which a survey consisting of the same data points was circulated within the global neurotrauma community. The survey results were disseminated in a final meeting to reach a consensus on the most pertinent registry variables.

Results: A total of 156 professionals from 53 countries, including both high-income countries and low- and middle-income countries, responded to the survey. The final consensus-based registry includes patients with TBI who required neurosurgical admission, a neurosurgical procedure, or a critical care admission. The data set comprised clinically pertinent information on demographics, injury characteristics, imaging, treatments, and short-term outcomes. Based on the consensus, the Global Epidemiology and Outcomes following Traumatic Brain Injury (GEO-TBI) registry was established.

Conclusion: The GEO-TBI registry will enable high-quality data collection, clinical auditing, and research activity, and it is supported by the World Federation of Neurosurgical Societies and the National Institute of Health Research Global Health Program. The GEO-TBI registry ( https://geotbi.org ) is now open for participant site recruitment. Any center involved in TBI management is welcome to join the collaboration to access the registry.

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References

1. Maas AIR, Menon DK, Adelson PD, et al. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017;16(12):987-1048.
1. Segui-Gomez M, MacKenzie EJ. Measuring the public health impact of injuries. Epidemiol Rev. 2003;25(1):3-19.
1. Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095-2128.
1. Dewan MC, Rattani A, Gupta S, et al. Estimating the global incidence of traumatic brain injury. J Neurosurg. 2018;130(4):1080-1097.
1. Rubiano AM, Carney N, Chesnut R, Puyana JC. Global neurotrauma research challenges and opportunities. Nature. 2015;527(7578):S193-S197.

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Consensus-Based Development of a Global Registry for Traumatic Brain Injury: Establishment, Protocol, and Implementation

Affiliations

Consensus-Based Development of a Global Registry for Traumatic Brain Injury: Establishment, Protocol, and Implementation

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical