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. 1986 Aug:18 Suppl:119-26.
doi: 10.1016/0031-6989(86)90044-5.

Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021

B Vilain, V Lagente, C Touvay, S Desquand, J Randon, J Lefort, P Braquet, B B Vargaftig

Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021

B Vilain et al. Pharmacol Res Commun. 1986 Aug.

Abstract

BN 52021 antagonized PAF-acether-induced bronchoconstriction (BC) in the guinea-pig and inhibited BC triggered by antigen in passively sensitized animals. The anti-anaphylactic activity was prevented by propranolol and may either result from an additional property of the drug, independent from PAF antagonism or from different PAF-dependent mechanisms with different responsiveness to the various antagonists.

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