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Case Reports
. 2024 Jan-Feb;99(1):131-134.
doi: 10.1016/j.abd.2022.06.008. Epub 2023 Sep 23.

Pigmented squamous cell carcinoma in a non-photo-exposed area of an indigenous woman

Luana Amaral de Moura  1 , Lucia Martins Diniz  2 , Emilly Neves Souza  2 , Lucas Amaral de Moura  3
Affiliations
Case Reports

Pigmented squamous cell carcinoma in a non-photo-exposed area of an indigenous woman

Luana Amaral de Moura et al. An Bras Dermatol. 2024 Jan-Feb.
No abstract available

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Figures

Figure 1
Figure 1
(A) On examination, an infiltrated erythematous-brownish plaque was observed, surmounted by a hyperkeratotic area, in the proximal lateral region of the left thigh (covered area). (B) Dermoscopy showing erythema and linear vessels in the central region, areas of black pigment and glomerular vessels and radiated pigment in the periphery.
Figure 2
Figure 2
Histopathology of an incisional biopsy, which suggested the diagnosis of pigmented SCC in situ. (A) Compact hyperkeratosis, acanthosis and pigment deposits, in addition to atypical keratinocytes and mitoses in the middle portion of the epidermis (Hematoxylin & eosin, ×40). (B) At higher magnification, atypical keratinocytes and mitoses (Hematoxylin & eosin, ×400).
Figure 3
Figure 3
Histopathology of the excisional biopsy. (A) Invasive cutaneous neoplasm consisting of atypical and pleomorphic cells with clear eosinophilic cytoplasm and pleomorphic nuclei with abundant keratinization (Hematoxylin & eosin, ×100). (B) Pigment deposits (Hematoxylin & eosin, ×40). (C) At higher magnification, keratinocyte atypia and pigment deposits (Hematoxylin & eosin, ×400).
Figure 4
Figure 4
Immunohistochemistry. (A) Positivity for EMA (epithelial membrane antigen). (B) Positivity for p63 protein.
See this image and copyright information in PMC

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