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Review
. 2023 Jul 14;44(7):598-601.
doi: 10.3760/cma.j.issn.0253-2727.2023.07.015.

[IGL-CCND1 positive mantle cell lymphoma: a case report and literature review]

[Article in Chinese]
Y C Zheng  1 , J W Zhao  1 , X Guo  1 , S H Yi  1 , Y Tao  1 , C W Li  1
Affiliations
Review

[IGL-CCND1 positive mantle cell lymphoma: a case report and literature review]

[Article in Chinese]
Y C Zheng et al. Zhonghua Xue Ye Xue Za Zhi. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

利益冲突 所有作者声明无利益冲突

Figures

图1
图1. 患者骨髓活检HE及免疫组化染色结果 A 骨髓活检中可见异型淋巴细胞增生，散在或簇状分布，胞体小至中等大，胞质量少，核略不规则，染色质粗（HE染色，×400）； B 免疫组化染色示肿瘤细胞CD20阳性（Elivision法，×400）； C CD5少量弱阳性（Elivision法染色，×400）； D cyclin D1部分阳性（Elivision法染色，×400）
图2
图2. 患者淋巴结切除活检HE及免疫组化染色结果 A 淋巴结结构完全破坏，异型淋巴细胞弥漫增生，胞体小至中等大，胞质量少，核略不规则，染色质粗（HE染色，×400）； B 免疫组化染色示肿瘤细胞CD20阳性（Elivision法染色，×400）； C CD5弱阳性（Elivision法染色，×400）； D cyclin D1弥漫阳性（Elivision法染色，×400）
图3
图3. 患者骨髓间期FISH结果 A CCND1（5′G /3′R）重排阳性，2F1G提示断裂点在5′端； B IGL（5′R/3′G）重排阳性，信号为1F1R1G； C IGL(G)/CCND1(R)重排阳性，信号1F2R2G提示复杂易位
图4
图4. 患者骨髓中期FISH结果 A 中期染色体核型； B 中期IGL(G)/CCND1(R)重排阳性，信号为1F1R2G，箭头显示融合信号在der(11)上
图5
图5. 本例套细胞淋巴瘤（MCL）患者细胞遗传学检验思路流程图
See this image and copyright information in PMC

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References

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