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. 2023 Dec;65(12):1757-1766.
doi: 10.1007/s00234-023-03221-x. Epub 2023 Sep 26.

Altered local spontaneous brain activity pattern in children with right-eye amblyopia of varying degrees: evidence from fMRI

Xiaopan Zhang  1   2 , Liang Liu  1   2 , Yadong Li  3 , Kejia Wang  3 , Guangying Zheng  3 , Yong Zhang  1   2 , Jingliang Cheng  1 , Baohong Wen  4
Affiliations

Altered local spontaneous brain activity pattern in children with right-eye amblyopia of varying degrees: evidence from fMRI

Xiaopan Zhang et al. Neuroradiology. 2023 Dec.

Abstract

Purpose: To investigate the abnormal changes of local brain activity in children with right-eye amblyopia of varying degrees.

Methods: Data of resting-state functional magnetic resonance imaging were collected from 16 children with severe amblyopia, 17 children with mild to moderate amblyopia, and 15 children with normal binocular vision. Local brain activity was analyzed using the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo).

Results: There were extensive ALFF differences among the three groups in 10 brain regions. There were extensive differences in ReHo among the three groups in 11 brain regions. The ALFF and ReHo of the right orbital part of the middle frontal gyrus displayed a significantly positive correlation with the best-corrected visual acuity of the right eye, respectively. The ALFF value and ReHo value of the right orbital part of the middle frontal gyrus followed the pattern of normal control < mild to moderate amblyopia < severe amblyopia.

Conclusion: This study demonstrated that there were changes in specific patterns of ALFF and ReHo in children with right-eye amblyopia of different degrees in brain regions performing visual sensorimotor and attentional control functions.

Keywords: Amblyopia; Amplitude of low-frequency fluctuations; Functional magnetic resonance imaging; Local spontaneous brain activity; Regional homogeneity.

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