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. 2023 Nov;20(11):e202301013.
doi: 10.1002/cbdv.202301013. Epub 2023 Oct 20.

A New 3-Benzylphthalide from the Moss Erythrodontium julaceum

Nguyen Ngoc Khanh Van  1 , Thammarat Aree  2 , Nguyen Thi Quynh Trang  3 , Nguyen Thi Ngoc Thao  3 , Nguyen Huu Tri  1 , Thuc-Huy Duong  4 , Ngoc-Hong Nguyen  5 , Pham Nguyen Kim Tuyen  3
Affiliations

A New 3-Benzylphthalide from the Moss Erythrodontium julaceum

Nguyen Ngoc Khanh Van et al. Chem Biodivers. 2023 Nov.

Abstract

From the moss Erythrodontium julaceum Paris growing in Vietnam, julacelide (1), a new 3-benzylphthalide, along with methyl orsellinate (2), ethyl orsellinate (3), 4-O-methylhaematommic acid (4), and zeorin (5), were isolated and structurally elucidated. Their chemical structures were elucidated through extensive 1D and 2D NMR analysis and high-resolution mass spectroscopy as well as through comparisons to the existing literature. Compound 4-O-methylhaematommic acid was a new natural product. The absolute configuration of julacelide was defined using time-dependent density functional theory (TDDFT) calculations. Julacelide was evaluated for α-glucosidase inhibition.

Keywords: 3-benzylphthalide; Erythrodontium julaceum; julacelide; moss; α-glucosidase inhibition.

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