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Review
. 2023 Aug 25;15(8):e44097.
doi: 10.7759/cureus.44097. eCollection 2023 Aug.

Orthostatic Hypotension in Benign Prostatic Hyperplasia Patients and Its Association With Alpha-1 Antagonist Use: A Comprehensive Literature Review

Muhammad Abubakar  1   2 , Rachna Prasad  3 , Siffat S Salim  4 , Deepak Basavaraju  5 , Munazza Khan  6 , Ibrahim K Lateef  6 , Ahmad Furqan  7 , Saud Raza  2 , Ishita Gupta  8 , Deepak Singla  9 , Hira Adil  10 , Ather Naeem  11
Affiliations
Review

Orthostatic Hypotension in Benign Prostatic Hyperplasia Patients and Its Association With Alpha-1 Antagonist Use: A Comprehensive Literature Review

Muhammad Abubakar et al. Cureus. .

Abstract

Orthostatic hypotension (OH) is frequently observed in benign prostatic hyperplasia (BPH) patients undergoing alpha-1 adrenergic antagonist (A1AA) therapy. While previous studies have acknowledged the prevalence of OH in BPH patients on A1AAs, limited data exist on ranking the safety of different A1AAs. This comprehensive review explores the underlying mechanisms of OH, examines numerous factors influencing its development, and provides insights into effective treatment strategies such as hydration, gradual postural changes, leg exercises, compression stockings, and tilt-table training for BPH management. The review highlights the significance of individualized care, interdisciplinary collaboration, and further research to optimize A1AA treatment, improve patient outcomes, and enhance quality of life.

Keywords: alpha-1 adrenergic antagonists; benign prostatic hyperplasia; lower urinary tract symptoms; orthostatic hypotension; quality of life.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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