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Review
. 2023 Dec;30(12):1324-1333.
doi: 10.1002/jhbp.1359. Epub 2023 Sep 26.

Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature

Adam Whitley  1   2 , Petr Kocián  3 , Andrej Nikov  1 , Denisa Krejčí  4   5 , Lucie Pehalová  4   5 , Milan Blaha  4   5 , Ladislav Dušek  4   5 , Robert Gürlich  1
Affiliations
Review

Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature

Adam Whitley et al. J Hepatobiliary Pancreat Sci. 2023 Dec.

Abstract

Background: The aim of this study was to compare trends in mortality and incidence, clinicopathological features and survival of patients diagnosed with pancreatic ductal adenocarcinoma under 50 years of age (early-onset pancreatic cancer [EOPC]) with patients diagnosed over 50 years of age (late-onset pancreatic cancer [LOPC]).

Methods: The national oncological registry of the Czech Republic was reviewed to identify all patients with histologically confirmed pancreatic ductal adenocarcinoma diagnosed between the years 1985 and 2015. Incidence, mortality, clinicopathological and survival data were analyzed and compared between patients with EOPC and LOPC.

Results: From a total of 18 888 patients included in the study, 1324 patients were under the age of 50 years (7.0%). The average annual percentage changes (AAPC) in incidence of all patients with EOPC was -1.0%. The APPC for male patients with EOPC was -2.0% and for female patients was +0.6%. The AAPC in incidence for LOPC was +1.3%. There were no differences in tumor stage, grade or location between EOPC and LOPC. Young patients were more frequently male (64.4% vs. 52.9%), more frequently underwent treatment and had better overall survival. The median survival interval for EOPC was 5.9 months and for LOPC was 4.5 months (p < .001).

Conclusions: The clinicopathological features of pancreatic ductal adenocarcinoma were similar in patients under and over the age of 50 years. Patients with EOPC survived longer than patients with LOPC. Continued efforts should be made to diagnose early and treat young patients aggressively.

Keywords: adult; pancreatic neoplasms; population register; survival; young adult.

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References

REFERENCES

    1. Scott AR, Stoltzfus KC, Tchelebi LT, Trifiletti DM, Lehrer EJ, Rao P, et al. Trends in cancer incidence in US adolescents and young adults, 1973-2015. JAMA Netw Open. 2020;3:e2027738.
    1. Sung H, Siegel RL, Rosenberg PS, Jemal A. Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry. Lancet Public Health. 2019;4:e137-e147.
    1. Kocián P, Svobodová I, Krejčí D, Blaha M, Gürlich R, Dušek L, et al. Is colorectal cancer a more aggressive disease in young patients? A population-based study from The Czech Republic. Cancer Epidemiol. 2019;63:101621.
    1. McWilliams RR, Maisonneuve P, Bamlet WR, Petersen GM, Li D, Risch HA, et al. Risk factors for early-onset and very-early-onset pancreatic adenocarcinoma. Pancreas. 2016;45(2):311-316.
    1. Eguchi H, Yamaue H, Unno M, Mizuma M, Hamada S, Igarashi H, et al. Clinicopathological characteristics of young patients with pancreatic cancer: an analysis of data from pancreatic cancer registry of Japan pancreas society. Pancreas. 2016;45:1411-1417.

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