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. 2023 Dec;25(6):e14153.
doi: 10.1111/tid.14153. Epub 2023 Sep 26.

Strongyloides infection screening in transplant candidates: What is the best strategy?

Ronaldo Cesar Borges Gryschek  1 , Marcelo Andreetta Corral  1 , Renata Barnabé Sitta  1 , Maiara Gottardi  1 , Ligia Camera Pierrotti  2 , Silvia Figueiredo Costa  2 , Edson Abdala  2 , Pedro Paulo Chieffi  3 , Fabiana Martins de Paula  1
Affiliations

Strongyloides infection screening in transplant candidates: What is the best strategy?

Ronaldo Cesar Borges Gryschek et al. Transpl Infect Dis. 2023 Dec.

Abstract

Background: The potential that Strongyloides stercoralis infection has to cause major morbidity and high mortality when the disseminated form occurs in transplant patients is of particular concern.

Methods: In this study, the objective was to observe S. stercoralis infection in patients who are candidates for transplantation by using parasitological, serological, and molecular techniques and to propose an algorithm for the detection of that infection in transplant candidates.

Results: By parasitological techniques, 10% of fecal samples were positive. Anti-Strongyloides antibodies immunoglobulin G were detected in 19.3% and 20.7% of patients by immunofluorescence assay and enzyme-linked immunosorbent assay, respectively. S. stercoralis DNA was observed in 17.3% of samples by conventional polymerase chain reaction and 32.7% of samples by quantitative polymerase chain reaction (qPCR).

Conclusion: The set of results allows us to reinforce that a positive result by parasitological techniques and/or qPCR indicates that the specific treatment should be applied. However, the improvement of diagnostic techniques may suggest changes in the screening for strongyloidiasis in these patients.

Keywords: Strongyloides infection; diagnosis methods; transplant candidates.

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References

REFERENCES

    1. Olsen A, van Lieshout L, Marti H, et al. Strongyloidiasis-the most neglected of the neglected tropical diseases? Trans R Soc Trop Med Hyg. 2009;103(10):967-972.
    1. Fleitas PE, Travacio M, Martí-Soler H, et al. The Strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review. PLoS Negl Trop Dis. 2020;14(4):e0008184.
    1. Mejia R, Nutman TB. Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis. Curr Opin Infect Dis. 2012;25(4):458-463.
    1. Marcos LA, Terashima A, Dupont HL, Gotuzzo E. Strongyloides hyperinfection syndrome: an emerging global infectious disease. Trans R Soc Trop Med Hyg. 2008;102(4):314-318.
    1. Roxby AC, Gottlieb GS, Limaye AP. Strongyloidiasis in transplant patients. Clin Infect Dis. 2009;49(9):1411-1423.

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