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. 2023 Nov:18:1235-1249.
doi: 10.2217/fmb-2023-0064. Epub 2023 Sep 26.

Bioefficacy of Sida cordifolia L. phytoextract against foodborne bacteria: optimization and bioactive compound analysis

Sachin Kumar  1 , Sandeep Kumar  1 , M Amin Mir  2 , Vineet Kumar Vishnoi  1 , Ashutosh Pandey  3 , Akanksha Pandey  1
Affiliations

Bioefficacy of Sida cordifolia L. phytoextract against foodborne bacteria: optimization and bioactive compound analysis

Sachin Kumar et al. Future Microbiol. 2023 Nov.

Abstract

Aim: To elucidate the antibacterial activity of Sida cordifolia L. phytoextract, evaluate its polyphenol profile and optimize conditions against certain common foodborne bacteria. Methods: After polarity-based sequential extraction, S. cordifolia phytoextracts were tested for antibacterial potential against antibiotic-resistant bacteria. Box-Behnken design was used to optimize several process parameters and ultra-performance liquid chromatography confirmed the phenolic composition of the best possible outcome. Results: Agar well diffusion and MIC/MBC assay confirmed a strong bactericidal effect of ethanolic (SC04-ET) extract against ampicillin and colistin-resistant Escherichia coli, Listeria monocytogenes and Staphylococcus aureus. The direct interactive effect of optimized conditions showed maximum antibacterial performance and ultra-performance liquid chromatography revealed a high amount of phenolic compounds. Conclusion: The results confirmed that ethanolic extract of S. cordifolia has potent bactericidal action against foodborne bacteria.

Keywords: Box-Behnken design; UPLC; antibacterial; antibiogram; bactericidal; polyphenol.

Plain language summary

What is this article about? There are bacteria in food that can make people ill. These are usually treated with antibiotics but sometimes, these bacteria become less susceptible to the antibiotics. This article looks at a natural alternative to antibiotics that is tested against three types of bacteria linked to foodborne illness. What were the results? This study found that the plant extract, a natural extract derived from different parts of plants such as leaves, stems or roots, can kill bacteria that are resistant to antibiotics. What do the results of the study mean? This study suggests that the plant extract could be a natural and effective way to kill bacteria. This could be useful in the food and medicine industries.

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