Normal meninges harbor oncogenic somatic mutations in meningioma-driver genes

Collaborators, Affiliations

Brainbank Neuro-CEB Neuropathology Network:
Franck Letournel, Marie-Laure Martin-Négrier, Maxime Faisant, Catherine Godfraind, Claude-Alain Maurage, Vincent Deramecourt, Mathilde Duchesne, David Meyronnet, Clémence Delteil, Valérie Rigau, Fanny Vandenbos-Burel, Danielle Seilhean, Susana Boluda, Isabelle Plu, Dan Christian Chiforeanu, Florent Marguet, Béatrice Lannes

¹ Sorbonne University, Paris Brain Institute, CRICM INSERM U1127 CNRS UMR 7225, APHP, 75013, Paris, France.
² Department of Neurosurgery, Gui de Chauliac Hospital, CHU de Montpellier, 34090, Montpellier, France.
³ Department of Neuropathology, AP-HP, Hôpital Pitié Salpétrière, 75013, Paris, France.
⁴ Department of Neurosurgery, APHP, Hopital Pitié Salpêtrière, 47-91 Bvd de l'Hopital, 75013, Paris, France.
⁵ Sorbonne University, Paris Brain Institute, CRICM INSERM U1127 CNRS UMR 7225, APHP, 75013, Paris, France. matthieu.peyre@aphp.fr.
⁶ Department of Neurosurgery, APHP, Hopital Pitié Salpêtrière, 47-91 Bvd de l'Hopital, 75013, Paris, France. matthieu.peyre@aphp.fr.

Julien Boetto et al. Acta Neuropathol. 2023 Dec.

. 2023 Dec;146(6):833-835.

doi: 10.1007/s00401-023-02635-4. Epub 2023 Sep 26.

Brainbank Neuro-CEB Neuropathology Network:
Franck Letournel, Marie-Laure Martin-Négrier, Maxime Faisant, Catherine Godfraind, Claude-Alain Maurage, Vincent Deramecourt, Mathilde Duchesne, David Meyronnet, Clémence Delteil, Valérie Rigau, Fanny Vandenbos-Burel, Danielle Seilhean, Susana Boluda, Isabelle Plu, Dan Christian Chiforeanu, Florent Marguet, Béatrice Lannes

¹ Sorbonne University, Paris Brain Institute, CRICM INSERM U1127 CNRS UMR 7225, APHP, 75013, Paris, France.
² Department of Neurosurgery, Gui de Chauliac Hospital, CHU de Montpellier, 34090, Montpellier, France.
³ Department of Neuropathology, AP-HP, Hôpital Pitié Salpétrière, 75013, Paris, France.
⁴ Department of Neurosurgery, APHP, Hopital Pitié Salpêtrière, 47-91 Bvd de l'Hopital, 75013, Paris, France.
⁵ Sorbonne University, Paris Brain Institute, CRICM INSERM U1127 CNRS UMR 7225, APHP, 75013, Paris, France. matthieu.peyre@aphp.fr.
⁶ Department of Neurosurgery, APHP, Hopital Pitié Salpêtrière, 47-91 Bvd de l'Hopital, 75013, Paris, France. matthieu.peyre@aphp.fr.

No abstract available

References

1. Abedalthagafi M, Bi WL, Aizer AA, Merrill PH, Brewster R, Agarwalla PK et al (2016) Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma. Neuro Oncol 18:649–655. https://doi.org/10.1093/neuonc/nov316 - DOI - PubMed - PMC
1. Achey RL, Gittleman H, Schroer J, Khanna V, Kruchko C, Barnholtz-Sloan JS (2019) Nonmalignant and malignant meningioma incidence and survival in the elderly, 2005–2015, using the Central Brain Tumor Registry of the United States. Neuro Oncol 21:380–391. https://doi.org/10.1093/neuonc/noy162 - DOI - PubMed
1. Argouarch AR, Schultz N, Yang AC, Jang Y, Garcia K, Cosme CG et al (2022) Postmortem human dura mater cells exhibit phenotypic, transcriptomic and genetic abnormalities that impact their use for disease modeling. Stem Cell Rev Rep 18:3050–3065. https://doi.org/10.1007/s12015-022-10416-x - DOI - PubMed - PMC
1. Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G et al (2013) Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet 45:285–289. https://doi.org/10.1038/ng.2526 - DOI - PubMed - PMC
1. Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K et al (2013) Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science 339:1077–1080. https://doi.org/10.1126/science.1233009 - DOI - PubMed - PMC