Interoception: Spinal sensory neurons that innervate the intestines

Truong Ly¹, Zachary A Knight²

Affiliations

¹ Department of Physiology, Kavli Institute for Fundamental Neuroscience, Neuroscience Graduate Program, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
² Department of Physiology, Kavli Institute for Fundamental Neuroscience, Neuroscience Graduate Program, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA. Electronic address: zachary.knight@ucsf.edu.

PMID: 37751704
DOI: 10.1016/j.cub.2023.07.066

Free article

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Interoception: Spinal sensory neurons that innervate the intestines

Truong Ly et al. Curr Biol. 2023.

Free article

. 2023 Sep 25;33(18):R945-R947.

doi: 10.1016/j.cub.2023.07.066.

Authors

Truong Ly¹, Zachary A Knight²

Affiliations

¹ Department of Physiology, Kavli Institute for Fundamental Neuroscience, Neuroscience Graduate Program, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
² Department of Physiology, Kavli Institute for Fundamental Neuroscience, Neuroscience Graduate Program, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA. Electronic address: zachary.knight@ucsf.edu.

PMID: 37751704
DOI: 10.1016/j.cub.2023.07.066

Abstract

The gut is innervated by sensory neurons that relay mechanical and chemical signals to the brain. Two new studies characterize the spinal sensory neurons that innervate the intestines and reveal a role for Piezo2 in these cells in sensing colonic distension and regulating gastrointestinal motility.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.
Wolfson RL, Abdelaziz A, Rankin G, Kushner S, Qi L, Mazor O, Choi S, Sharma N, Ginty DD. Wolfson RL, et al. Cell. 2023 Aug 3;186(16):3368-3385.e18. doi: 10.1016/j.cell.2023.07.007. Cell. 2023. PMID: 37541195 Free PMC article.
PIEZO2 in somatosensory neurons controls gastrointestinal transit.
Servin-Vences MR, Lam RM, Koolen A, Wang Y, Saade DN, Loud M, Kacmaz H, Frausto S, Zhang Y, Beyder A, Marshall KL, Bönnemann CG, Chesler AT, Patapoutian A. Servin-Vences MR, et al. Cell. 2023 Aug 3;186(16):3386-3399.e15. doi: 10.1016/j.cell.2023.07.006. Cell. 2023. PMID: 37541196 Free PMC article.

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Interoception: Spinal sensory neurons that innervate the intestines

Affiliations

Interoception: Spinal sensory neurons that innervate the intestines

Authors

Affiliations

Abstract

Conflict of interest statement

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