Regeneration: Signaling superhighways
- PMID: 37751705
- DOI: 10.1016/j.cub.2023.08.024
Regeneration: Signaling superhighways
Abstract
Regeneration requires the collective effort of multiple organ systems. A recent study of planarian whole-body regeneration finds that Erk kinase activity propagates rapidly across the entire animal through longitudinal muscle cells to coordinate animal-wide wound responses and that this signal propagation is required for regeneration.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Ultrafast distant wound response is essential for whole-body regeneration.Cell. 2023 Aug 17;186(17):3606-3618.e16. doi: 10.1016/j.cell.2023.06.019. Epub 2023 Jul 21. Cell. 2023. PMID: 37480850 Free PMC article.
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