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Review
. 2023 Oct;43(5):689-698.
doi: 10.1055/s-0043-1775764. Epub 2023 Sep 26.

Blood-Based Biomarkers for Neuroprognostication in Acute Brain Injury

Andrew M Nguyen  1 , Vishal Saini  1 , H E Hinson  2
Affiliations
Review

Blood-Based Biomarkers for Neuroprognostication in Acute Brain Injury

Andrew M Nguyen et al. Semin Neurol. 2023 Oct.

Abstract

Acute brain injury causes loss of functionality in patients that often is devastating. Predicting the degree of functional loss and overall prognosis requires a multifaceted approach to help patients, and more so their families, make important decisions regarding plans and goals of care. A variety of blood-based markers have been studied as one aspect of this determination. In this review, we discuss CNS-derived and systemic markers that have been studied for neuroprognostication purposes. We discuss the foundation of each protein, the conditions in which it has been studied, and how the literature has used these markers for interpretation. We also discuss challenges to using each marker in each section as well.

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Conflict of interest statement

None declared.

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