Late effects in survivors of infant acute lymphoblastic leukaemia-a study of the Australian and New Zealand Children's Haematology/Oncology Group

Denitza Mironova¹, Chitra M Saraswati², Peter Downie^{3

4}, Chow Yee Lai^{3

4}, Eleanor Cook⁵, Vickyanne Carruthers⁶, Perla Moukhaiber⁷, Fiona Molloy⁸, Joshua Serov⁹, Elizabeth McKinnon², Frank Alvaro⁹, Michael Osborn⁶, Tamas Revesz⁶, Tim Prestidge¹⁰, Siobhan Cross¹¹, Caroline M Bateman⁷, Andrew S Moore⁸, Seong Lin Khaw⁴, Marion K Mateos^{5

12}, Rishi S Kotecha^{13

14

15}

Affiliations

¹ Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Australia.
² Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.
³ Children's Cancer Centre, Monash Children's Hospital, Monash Health, Clayton, Australia.
⁴ Children's Cancer Centre, The Royal Children's Hospital, Melbourne, Australia.
⁵ Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia.
⁶ Department of Clinical Haematology and Oncology, Women's and Children's Hospital, North Adelaide, Australia.
⁷ Cancer Centre for Children, The Children's Hospital at Westmead, Sydney, Australia.
⁸ Oncology Service, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.
⁹ Children's Cancer and Blood Disorders, John Hunter Children's Hospital, Newcastle, Australia.
¹⁰ Blood and Cancer Centre, Starship Children's Hospital, Auckland, New Zealand.
¹¹ Children's Haematology Oncology Centre, Christchurch Hospital, Christchurch, New Zealand.
¹² Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Kensington, Australia.
¹³ Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Australia. rishi.kotecha@health.wa.gov.au.
¹⁴ Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia. rishi.kotecha@health.wa.gov.au.
¹⁵ Curtin Medical School, Curtin University, Perth, Australia. rishi.kotecha@health.wa.gov.au.

PMID: 37752126
PMCID: PMC10522653
DOI: 10.1038/s41408-023-00924-5

Late effects in survivors of infant acute lymphoblastic leukaemia-a study of the Australian and New Zealand Children's Haematology/Oncology Group

Denitza Mironova et al. Blood Cancer J. 2023.

. 2023 Sep 26;13(1):150.

doi: 10.1038/s41408-023-00924-5.

Authors

Affiliations

¹ Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Australia.
² Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.
³ Children's Cancer Centre, Monash Children's Hospital, Monash Health, Clayton, Australia.
⁴ Children's Cancer Centre, The Royal Children's Hospital, Melbourne, Australia.
⁵ Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia.
⁶ Department of Clinical Haematology and Oncology, Women's and Children's Hospital, North Adelaide, Australia.
⁷ Cancer Centre for Children, The Children's Hospital at Westmead, Sydney, Australia.
⁸ Oncology Service, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.
⁹ Children's Cancer and Blood Disorders, John Hunter Children's Hospital, Newcastle, Australia.
¹⁰ Blood and Cancer Centre, Starship Children's Hospital, Auckland, New Zealand.
¹¹ Children's Haematology Oncology Centre, Christchurch Hospital, Christchurch, New Zealand.
¹² Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Kensington, Australia.
¹³ Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Australia. rishi.kotecha@health.wa.gov.au.
¹⁴ Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia. rishi.kotecha@health.wa.gov.au.
¹⁵ Curtin Medical School, Curtin University, Perth, Australia. rishi.kotecha@health.wa.gov.au.

PMID: 37752126
PMCID: PMC10522653
DOI: 10.1038/s41408-023-00924-5

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1**
Kaplan–Meier survival curves showing 5-year event-free and overall survival of infants with acute lymphoblastic leukaemia treated in Australia and New Zealand between 1 January 1992 to 31 December 2011.

See this image and copyright information in PMC

References

1. SEER*Explorer: An interactive website for SEER cancer statistics. Surveillance Research Program, National Cancer Institute; 2023 Apr 19. [cited 2023 May 31]. Available from: https://seer.cancer.gov/statistics-network/explorer/. Data source(s): SEER Incidence Data, November 2022 Submission (1975–2020), SEER 22 registries.
1. Breese EH, Kotecha RS, Guest EM. Acute lymphoblastic leukemia in infants; a distinctive, high-risk subtype of childhood acute lymphoblastic leukemia. In: Litzow MR, Raetz EA, editors. Clinical management of acute lymphoblastic leukemia: from bench to bedside. Switzerland: Springer; 2022. pp. 135–48.
1. Kotecha RS. Updates in infant acute lymphoblastic leukemia and the potential for targeted therapy. Hematol Am Soc Hematol Educ Program. 2022;2022:611–7. doi: 10.1182/hematology.2022000359. - DOI - PMC - PubMed
1. Pieters R, de Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, et al. Outcome of infants younger than 1 year with acute lymphoblastic leukemia treated with the Interfant-06 protocol: results from an international phase III randomized study. J Clin Oncol. 2019;37:2246–56. doi: 10.1200/JCO.19.00261. - DOI - PubMed
1. Kotecha RS, Gottardo NG, Kees UR, Cole CH. The evolution of clinical trials for infant acute lymphoblastic leukemia. Blood Cancer J. 2014;4:e200. doi: 10.1038/bcj.2014.17. - DOI - PMC - PubMed

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Late effects in survivors of infant acute lymphoblastic leukaemia-a study of the Australian and New Zealand Children's Haematology/Oncology Group

Affiliations

Late effects in survivors of infant acute lymphoblastic leukaemia-a study of the Australian and New Zealand Children's Haematology/Oncology Group

Authors

Affiliations

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources