Antipsychotic displays dual GPCR binding mode

Comment

Sarah Crunkhorn. Nat Rev Drug Discov. 2023 Nov.

. 2023 Nov;22(11):869.

doi: 10.1038/d41573-023-00154-1.

No abstract available

Comment on

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M₄ mAChR.
Burger WAC, Pham V, Vuckovic Z, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM. Burger WAC, et al. Nat Commun. 2023 Sep 6;14(1):5440. doi: 10.1038/s41467-023-41199-5. Nat Commun. 2023. PMID: 37673901 Free PMC article.

1. Burger, W. A. C. et al. Xanomeline displays concomitant orthosteric and allosteric binding modes at the M₄ mAChR. Nat. Commun. 14, 5440 (2023) - PubMed - DOI - PMC