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Disclosures Dr Butt reports advisory board honoraria from Bayer, consultant honoraria from Novartis and AstraZeneca, and travel grants from AstraZeneca, outside the submitted work. Dr Nielsen reports grants from the Novo Nordisk Foundation (NNF16OC0018658 and NNF17OC0029148), outside the submitted work. Dr Kristensen reports advisory honoraria from Bayer and AstraZeneca, outside the submitted work. Dr Svendsen reports honoraria from Medtronic (speaker fee and membership of advisory committee) and research grant from Medtronic, outside the submitted work. Dr Pehrson reports honoraria (speaker fees) from AstraZeneca, Bristol Myers Squibb, and Abbott, outside the submitted work. Dr Hassager reports grants from the Novo Nordisk Foundation, the Lundbeck Foundation, and the Danish Heart Foundation, outside the submitted work. Dr Bruun reports grants from the Novo Nordisk Foundation, Health Insurance Denmark, the Augustinus Foundation, and the Kaj Hansen Foundation, outside the submitted work. Dr Gustafsson reports research grants from Pfizer and the Novo Nordisk Foundation, advisory board honoraria from Bayer, Pfizer, Abbott, Ionis, and Alnylam, and speakers’ fee from AstraZeneca, Novartis, and Orion Pharma, outside the submitted work. The other authors report no conflicts.