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. 2023 Sep 15;11(3):122.
doi: 10.3390/diseases11030122.

Proportion of Respiratory Syncytial Virus, SARS-CoV-2, Influenza A/B, and Adenovirus Cases via Rapid Tests in the Community during Winter 2023-A Cross Sectional Study

Dimitrios Papagiannis  1 , Garifallia Perlepe  2 , Theodora Tendolouri  3 , Polyxeni Karakitsiou  4 , Georgia Damagka  5 , Anna Kalaitzi  6 , Sofia Alevra  6 , Foteini Malli  7 , Konstantinos I Gourgoulianis  2
Affiliations

Proportion of Respiratory Syncytial Virus, SARS-CoV-2, Influenza A/B, and Adenovirus Cases via Rapid Tests in the Community during Winter 2023-A Cross Sectional Study

Dimitrios Papagiannis et al. Diseases. .

Abstract

Respiratory infections constitute a major reason for infants and children seeking medical advice and visiting health facilities, thus remaining a significant public threat with high morbidity and mortality. The predominant viruses causing viral respiratory infections are influenza A and B viruses (Flu-A, Flu-B), respiratory syncytial virus (RSV), adenovirus and coronaviruses. We aimed to record the proportion of RSV, SARS-CoV-2, influenza A/B and adenovirus cases with rapid antigen tests and validate the results with RT-PCR assays of upper respiratory specimens with a wide range of viral loads and (co)-infection patterns in children. Clinical samples were collected from early symptomatic children (presenting with fever and/or cough and/or headache within 5-7 days). The surveillance program was conducted in five private pediatric dispensaries and one pediatric care unit, from 10 January 2023 to 30 March 2023 in central Greece. The total sample of specimens collected was 784 young children and infants, of which 383 (48.8%) were female and 401 were male (51.2%). The mean age of participants was 7.3 + 5.5 years. The sensitivity of the FLU A & B test was 91.15% (95% CI: 84.33-95.67%), and the specificity was 98.96% (95% CI: 97.86-99.58%). The sensitivity and specificity of the adenovirus and RSV test was {92.45% (95% CI: 81.79-97.91%), 99.32% (95% CI: 98.41-99.78%)} and {92.59% (95% CI: 75.71-99.09%), 99.47% (95% CI: 98.65-99.86%)} respectively. Lastly, the sensitivity of the SARS-CoV-2 test was 100.00% (95% CI: 79.41-100.00%) and the specificity was 99.74% (95% CI: 99.06-99.97%). We recorded a proportion of 14.3% and 3.44% for influenza A and B, respectively, followed by a proportion of 6.9% for adenovirus, a proportion of 3.7% for RSV, and finally, a proportion of 2.3% for SARS-CoV-2. The combination of a new multiple rapid test with multiple antigens will probably be a useful tool with a financial impact for health systems targeting the early detection and appropriate treatment of respiratory infections in emergency departments in primary health care facilities.

Keywords: RSV; SARS-CoV-2; adenovirus; influenza A/B; rapid test; vaccinations.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Peeling R.W., Olliaro P.L., Boeras D.I., Fongwen N. Scaling up COVID-19 rapid antigen tests: Promises and challenges. Lancet Infect. Dis. 2021;21:E290–E295. doi: 10.1016/S1473-3099(21)00048-7. - DOI - PMC - PubMed
    1. Yamayoshi S., Sakai-Tagawa Y., Koga M., Akasaka O., Nakachi I., Koh H., Maeda K., Adachi E., Saito M., Nagai H., et al. Comparison of Rapid Antigen Tests for COVID-19. Viruses. 2020;12:1420. doi: 10.3390/v12121420. - DOI - PMC - PubMed
    1. Miller T.E., Beltran W.F.G., Bard A.Z., Gogakos T., Anahtar M.N., Astudillo M.G., Yang D., Thierauf J., Fisch A.S., Mahowald G.K., et al. Clinical sensitivity and interpretation of PCR and serological COVID-19 diagnostics for patients presenting to the hospital. FASEB J. 2020;34:13877–13884. doi: 10.1096/fj.202001700RR. - DOI - PMC - PubMed
    1. Scohy A., Anantharajah A., Bodéus M., Kabamba-Mukadi B., Verroken A., Rodriguez-Villalobos H. Low performance of rapid antigen detection test as frontline testing for COVID-19 diagnosis. J. Clin. Virol. 2020;129:104455. doi: 10.1016/j.jcv.2020.104455. - DOI - PMC - PubMed
    1. Shi T., McAllister D.A., O’Brien K.L., Simoes E.A., Madhi S.A., Gessner B.D., Nair H. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: A systematic review and modelling study. Lancet. 2017;390:946–958. doi: 10.1016/S0140-6736(17)30938-8. - DOI - PMC - PubMed

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