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. 2023 Aug 25;9(9):687.
doi: 10.3390/gels9090687.

Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast Orodispersible Drug Delivery

Barbara Jadach  1 , Martyna Misek  1 , Jan Ferlak  1
Affiliations

Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast Orodispersible Drug Delivery

Barbara Jadach et al. Gels. .

Abstract

The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline cellulose was used as the disintegrant. Meloxicam (MLX), the drug used to treat rheumatic diseases for children and adults, was proposed as the active pharmaceutical ingredient (API). The influence of the polymer and disintegrant on the properties of ODF was investigated. The evaluation of prepared gel films was based on appearance description, mass uniformity measurement, disintegration time, API content, film wettability, and water content. Also, the dissolution test was prepared in a basket apparatus using artificial salvia (pH = 6.8) as the medium. The obtained API release profiles were analyzed for the similarity factors (f2) with the DDSolver software. The results showed that independently of the polymer or disintegrant, using the solvent casting method, gel films have a similar appearance and active substance content close to the theoretical value and water content of less than 10%. Only the type of polymer influences the release profiles of MLX. However, the disintegration time was longer than 30 s, which makes the films non-fast-dissolving drug delivery systems. This means that for the ODF system, further evaluation is required, and some changes in the composition of the film have to be done.

Keywords: dissolution; fast disintegration; meloxicam; orodispersible gel film; polymer gel film.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structure of hypromelose. * point of attachement of the residue to the molecule.
Figure 2
Figure 2
Structure of sodium alginate [19].
Figure 3
Figure 3
Structure of the meloxicam.
Figure 4
Figure 4
Appearance of prepared gel films.
Figure 5
Figure 5
Comparison of water content in prepared films.
Figure 6
Figure 6
Uptake of water of films: (A) growth of mass of films during first 3 h; (B) growth of mass during 14 days.
Figure 7
Figure 7
Comparison of MLX release profiles.
Figure 8
Figure 8
Explanation of the content of MLX in gel films. (Numbers 1–3 determine the places of cut of small films, also marked in the figure).
Figure 9
Figure 9
Endpoint of disintegration time.
See this image and copyright information in PMC

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