The Current Trend of Radiation Therapy for Patients with Localized Prostate Cancer
- PMID: 37754502
- PMCID: PMC10529045
- DOI: 10.3390/curroncol30090587
The Current Trend of Radiation Therapy for Patients with Localized Prostate Cancer
Abstract
A recent approach to radiotherapy for prostate cancer is the administration of high doses of radiation to the prostate while minimizing the risk of side effects. Thus, image-guided radiotherapy utilizes advanced imaging techniques and is a feasible strategy for increasing the radiation dose. New radioactive particles are another approach to achieving high doses and safe procedures. Prostate brachytherapy is currently considered as a combination therapy. Spacers are useful to protect adjacent organs, specifically the rectum, from excessive radiation exposure.
Keywords: brachytherapy; hydrogel spacer; image-guided radiation therapy; intensity-modulated radiation therapy; metastasis direct therapy; prostate cancer; radiation therapy; stereotactic body radiation therapy; volumetric modulated arc therapy.
Conflict of interest statement
The authors declare no conflict of interest. The funders had no role in the study design; data collection, analyses, or interpretation; writing of the manuscript; or decision to publish the results.
Figures

Similar articles
-
[High dose for prostate irradiation with image guided radiotherapy: contribution of intensity modulation arctherapy].Cancer Radiother. 2010 Dec;14(8):679-89. doi: 10.1016/j.canrad.2010.03.003. Epub 2010 May 31. Cancer Radiother. 2010. PMID: 20570202 Clinical Trial. French.
-
Comparison of rectal dose reduction by a hydrogel spacer among 3D conformal radiotherapy, volumetric-modulated arc therapy, helical tomotherapy, CyberKnife and proton therapy.J Radiat Res. 2020 May 22;61(3):487-493. doi: 10.1093/jrr/rraa013. J Radiat Res. 2020. PMID: 32211861 Free PMC article.
-
Rectal radiation dose-reduction techniques in prostate cancer: a focus on the rectal spacer.Future Oncol. 2018 Nov;14(26):2773-2788. doi: 10.2217/fon-2018-0286. Epub 2018 Jun 25. Future Oncol. 2018. PMID: 29939069 Review.
-
Hydrogel Spacer Prospective Multicenter Randomized Controlled Pivotal Trial: Dosimetric and Clinical Effects of Perirectal Spacer Application in Men Undergoing Prostate Image Guided Intensity Modulated Radiation Therapy.Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):971-977. doi: 10.1016/j.ijrobp.2015.04.030. Epub 2015 Apr 23. Int J Radiat Oncol Biol Phys. 2015. PMID: 26054865 Clinical Trial.
-
Current status of intensity-modulated radiation therapy for prostate cancer: History, clinical results and future directions.Int J Urol. 2019 Aug;26(8):775-784. doi: 10.1111/iju.14011. Epub 2019 May 21. Int J Urol. 2019. PMID: 31115116 Review.
Cited by
-
[Contemporary treatment standards and trends of systemic therapy in metastatic hormone-sensitive prostate cancer-implementing study data in clinical practice].Urologie. 2024 Dec;63(12):1259-1265. doi: 10.1007/s00120-024-02410-7. Epub 2024 Aug 14. Urologie. 2024. PMID: 39143396 Free PMC article. German.
-
MicroRNAs: Novel clinical biomarkers for cancer radiotherapy (Review).Mol Med Rep. 2025 Sep;32(3):254. doi: 10.3892/mmr.2025.13619. Epub 2025 Jul 11. Mol Med Rep. 2025. PMID: 40641137 Free PMC article. Review.
-
Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications.Eur J Med Res. 2025 Feb 27;30(1):140. doi: 10.1186/s40001-025-02382-0. Eur J Med Res. 2025. PMID: 40016786 Free PMC article. Review.
-
The Role of Transurethral BPH Surgeries in Management of Urinary Symptoms in Prostate Cancer Patients, Narrative Review.Curr Urol Rep. 2024 Oct 1;26(1):7. doi: 10.1007/s11934-024-01229-1. Curr Urol Rep. 2024. PMID: 39352587 Free PMC article. Review.
-
Echolaser Focal Treatment for Prostate Cancer Guided by Fiducial Marker Placement.Cancers (Basel). 2025 May 20;17(10):1707. doi: 10.3390/cancers17101707. Cancers (Basel). 2025. PMID: 40427204 Free PMC article.
References
-
- Gillessen S., Bossi A., Davis I.D., de Bono J., Fizazi K., James N.D., Mottet N., Shore N., Small E., Smith M., et al. Management of Patients with Advanced Prostate Cancer. Part I: Intermediate-/High-risk and Locally Advanced Disease, Biochemical Relapse, and Side Effects of Hormonal Treatment: Report of the Advanced Prostate Cancer Consensus Conference 2022. Eur. Urol. 2023;83:267–293. doi: 10.1016/j.eururo.2022.11.002. - DOI - PMC - PubMed
-
- Donovan J.L., Hamdy F.C., Lane J.A., Mason M., Metcalfe C., Walsh E., Blazeby J.M., Peters T.J., Holding P., Bonnington S., et al. Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer. N. Engl. J. Med. 2016;375:1425–1437. doi: 10.1056/NEJMoa1606221. - DOI - PMC - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical