Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug 24;9(9):875.
doi: 10.3390/jof9090875.

Antibacterial Polyketides Isolated from the Marine-Derived Fungus Fusarium solani 8388

Cankai Lin  1 , Rongchun Huang  1 , Juntao Liu  1 , Hong Li  1 , Liping Zhu  1 , Xin Huang  1 , Bo Ding  1 , Lan Liu  2 , Hongbo Huang  1 , Yiwen Tao  1
Affiliations

Antibacterial Polyketides Isolated from the Marine-Derived Fungus Fusarium solani 8388

Cankai Lin et al. J Fungi (Basel). .

Abstract

Seven new polyketides named fusarisolins F-K (1-6) and fusarin I (7) were isolated from the marine-derived fungus Fusarium solani 8388, together with the known anhydrojavanicin (8), 5-deoxybostry coidin (9), and scytalol A (10). Their structures were established by comprehensive spectroscopic data analyses, and by comparison of the 1H and 13C NMR data with those reported in literature. Fusarisolin F (1) contained both a dichlorobenzene group and an ethylene oxide unit, which was rare in nature. In the bioassays, fusarisolin I (4), fusarisolin J (5), and 5-deoxybostry coidin (9) exhibited obvious antibacterial activities against methicillin-resistant Staphylococcus aureus n315 with MIC values of 3, 3, and 6 μg/mL, respectively. Fusarisolin H (3) and fusarisolin J (5) showed inhibitory effects against methicillin-resistant Staphylococcus aureus NCTC 10442 with the same MIC value of 6 μg/mL. With the exception of 5, all other compounds did not show or showed weak cytotoxicities against HeLa, A549, and KB cells; while fusarisolin J (5) demonstrated moderate cytotoxicities against the three human cancer cell lines with CC50 values between 9.21 and 14.02 μM.

Keywords: Fusarium solani; antibacterial; cytotoxicity; fungus; marine microorganism; polyketide.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of 1–10 isolated from the Fusarium solani 8388.
Figure 2
Figure 2
Selected HMBC correlations of 1 and 2, and key NOE correlations of 2.
Figure 3
Figure 3
The ORTEP drawing of the crystal structure of compound 1.
Figure 4
Figure 4
Selected COSY and HMBC correlations of compounds 3–5.
Figure 5
Figure 5
(A) Comparison of the experimental and the calculated ECD spectra of 3; (B) the ECD spectrum of 4.
Figure 6
Figure 6
Comparison of the experimental and the calculated ECD spectra of 5.
Figure 7
Figure 7
Selected COSY and HMBC correlations of compounds 6 and 7, and NOESY correlations of compound 6.
Figure 8
Figure 8
Comparison of the experimental and calculated ECD spectra of 6 (A) and 7 (B).
See this image and copyright information in PMC

References

    1. Blunt J.W., Copp B.R., Keyzers R.A., Munro M.H.G., Prinsep M.R. Marine natural products. Nat. Prod. Rep. 2015;32:116–211. doi: 10.1039/C4NP00144C. - DOI - PubMed
    1. Sun C.X., Mudassir S., Zhang Z.Z., Feng Y.Y., Chang Y.M., Che Q., Gu Q.Q., Zhu T.J., Zhang G.J., Li D.H. Secondary metabolites from deep-sea derived microorganisms. Curr. Med. Chem. 2020;27:6244–6273. doi: 10.2174/0929867326666190618153950. - DOI - PubMed
    1. Li M.Z., Yu R.L., Bai X.L., Wang H., Zhang H.W. Fusarium: A treasure trove of bioactive secondary metabolites. Nat. Prod. Rep. 2020;37:1568–1588. doi: 10.1039/D0NP00038H. - DOI - PubMed
    1. Manning B.B., Abbas H.K. The effect of Fusarium mycotoxins deoxynivalenol, fumonisin, and moniliformin from contaminated moldy grains on aquaculture fish. Toxin Rev. 2012;31:11–15. doi: 10.3109/15569543.2011.651519. - DOI
    1. Antonissen G., Martel A., Pasmans F., Ducatelle R., Verbrugghe E., Vandenbroucke V., Li S.J., Haesebrouck F., Van Immerseel F., Croubels S. The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases. Toxins. 2014;6:430–452. doi: 10.3390/toxins6020430. - DOI - PMC - PubMed

LinkOut - more resources