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. 2024 Apr;40(4):253-256.
doi: 10.1089/AID.2023.0050. Epub 2023 Oct 18.

No Association Between HLA-B*57:01 and Prevalence and/or Outcome of Progressive Multifocal Leukoencephalopathy in a French Nationwide Human Immunodeficiency Virus Cohort

Solène Secher  1 , Maxime Hentzien  2 , Lise Cuzin  3 , Christine Jacomet  4 , Laurent Hocqueloux  5 , David Rey  6 , Amélie Menard  7 , Cédric Arvieux  8 , François Raffi  1 , Firouzé Bani-Sadr  2
Affiliations

No Association Between HLA-B*57:01 and Prevalence and/or Outcome of Progressive Multifocal Leukoencephalopathy in a French Nationwide Human Immunodeficiency Virus Cohort

Solène Secher et al. AIDS Res Hum Retroviruses. 2024 Apr.

Abstract

Among 34,351 patients living with human immunodeficiency virus with available HLA-B*57:01 included in the Dat'AIDS cohort, 194 patients (0.56%) had a history of progressive multifocal leukoencephalopathy (PML) and 1,746 (5.08%) were carriers of HLA-B*57:01. The frequency of HLA-B*57:01 was similar among patients with history of PML compared with patients without a history of PML (6.19% [95% confidence interval, CI 2.8%-9.6%] vs. 5.08% [95% CI 4.8%-5.3%]; p = .48). Among patients with PML, clinical and biological characteristics at PML diagnosis and the PML outcome were not different according to HLA-B*57:01 status.

Keywords: Dat'AIDS cohort; HIV; HLA-B*57:01; progressive multifocal leukoencephalopathy.

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