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Review
. 2023 Dec;55(2):2261964.
doi: 10.1080/07853890.2023.2261964. Epub 2023 Sep 27.

Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review

Chao Wang  1 , Min Wang  2 , Guanjian Li  1 , Bing Song  1 , Qiong Xing  3 , Yunxia Cao  1   3
Affiliations
Review

Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review

Chao Wang et al. Ann Med. 2023 Dec.

Abstract

Although vaccination with the Coronavirus disease 2019 vaccine is important and effective in the prevention of SARS-CoV-2 infection, the public expressed concerns regarding the adverse effects of vaccine on fertility. Some reviews have focused on it, they have been unable to collect sufficient research data because of the earlier publication period. As relevant evidence has gradually increased, we reviewed these studies from the perspectives of males, females with or without pregnancy, and different vaccine types. The results suggest that although males may experience fluctuations in semen parameters within their physiological ranges after receiving the vaccine, it has not yet reached a level of influence on the partner's pregnancy probability. As to female without pregnancy, it is believed that vaccination will not affect fertility; however, more research is needed to explore the short-term impact. Vaccination during any trimester is considered safe in pregnant women.

Keywords: COVID-19; SARS-CoV-2; fertility; vaccine.

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Conflict of interest statement

The authors report there are no competing interests to declare.

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