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Comment
. 2023 Dec 1;29(23):4706-4708.
doi: 10.1158/1078-0432.CCR-23-2152.

Time to Think about HLA-Based Diagnostics in Lung Cancer?

Anastasios Dimou  1
Affiliations
Comment

Time to Think about HLA-Based Diagnostics in Lung Cancer?

Anastasios Dimou. Clin Cancer Res. .

Abstract

HLA evolutionary divergence reflects the ability to recognize diverse neoantigens as non-self, and as a biomarker is conceptually distinct from programmed cell death ligand 1 expression and tumor mutation burden. HLA-based assays to predict benefit from immunotherapy in lung cancer require prospective validation. See related article by Jiang et al., p. 4830.

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