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Comment
. 2023 Oct 24;119(13):e146-e148.
doi: 10.1093/cvr/cvad131.

LDL's unexpected travel partners in the road to atherosclerosis

Soumaya Ben-Aicha  1 , Borja Ibañez  2   3   4
Affiliations
Comment

LDL's unexpected travel partners in the road to atherosclerosis

Soumaya Ben-Aicha et al. Cardiovasc Res. .
No abstract available

Keywords: CVD; LDL; Macrophage; TLR8; sRNA.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Depicts the interaction and exchange of signalling between various components within the atherosclerotic plaque, including LDL and macrophages. Researchers have discovered that msRNAs are abundant on LDL and can activate TLR8, leading to pro-inflammatory macrophage polarization and cytokine secretion. The use of non-targeting locked nucleic acids to competitively antagonize TLR8 prevented macrophage polarization induced by native LDL in vitro and re-organized lesion macrophage phenotypes in vivo, as identified by single-cell RNA sequencing. These results suggest that LDL-msRNA instigates inflammation associated with atherosclerosis and supports alternative functions of LDL beyond cholesterol transport.
See this image and copyright information in PMC

Comment on

  • LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8.
    Allen RM, Michell DL, Cavnar AB, Zhu W, Makhijani N, Contreras DM, Raby CA, Semler EM, DeJulius C, Castleberry M, Zhang Y, Ramirez-Solano M, Zhao S, Duvall C, Doran AC, Sheng Q, Linton MF, Vickers KC. Allen RM, et al. Nat Cell Biol. 2022 Dec;24(12):1701-1713. doi: 10.1038/s41556-022-01030-7. Epub 2022 Dec 6. Nat Cell Biol. 2022. PMID: 36474072 Free PMC article.

References

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