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. 2023 Nov;55(9):2121-2125.
doi: 10.1016/j.transproceed.2023.08.004. Epub 2023 Sep 26.

Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure

Michele Luglio  1 , Tatiana de Carvalho Silva Marques  2 , Maria Fernanda Badue Pereira  3 , Artur Figueiredo Delgado  2 , Werther Brunow de Carvalho  2 , Ana Cristina Aoun Tannuri  4 , Natascha Silva Sandy  5 , Nadia Litvinov  3 , Camila Sanson Yoshino de Paula  3 , Ariane Guissi Dos Santos  3 , Carolina Dos Santos Lazari  6 , Michele Soares Gomes Gouvea  7 , Anderson Vicente de Paula  7 , Tania Regina Tozetto Mendoza  7 , Ryan Yukimatsu Tanigawa  8 , Fabiana Roberto Lima  8 , André Bubna Hirayama  8 , Isabela Gusson Galdino Dos Santos  4 , João Renato Rebello Pinho  7 , Ester Cerdeira Sabino  7 , Maria Cassia Mendes-Correah  7 , Venancio Avancini Ferreira Alves  8 , Heloisa Helena de Sousa Marques  3
Affiliations

Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure

Michele Luglio et al. Transplant Proc. 2023 Nov.

Abstract

A new outbreak of hepatitis of unknown origin raised awareness in the international community. A few reports have attempted to associate new cases with adenovirus infection and the immunologic effects of previous SARS-CoV-2 infections through a superantigen mechanism. Moreover, according to a case series, viral isolates were identified in 7 of 10 cases of pediatric patients with hepatitis of unknown origin and acute liver failure. Adenovirus was detected by respiratory secretion polymerase chain reaction in 2 patients, with neither presenting with SARS-CoV-2 acute infection. Clinical and laboratory descriptions and cross-referencing epidemiologic and pathophysiological data can help identify possible disease etiologies.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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