Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec;76(12):706-710.
doi: 10.1038/s41429-023-00657-4. Epub 2023 Sep 27.

A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921

Arisu Tahara  1 , Kazuki Tani  1 , Miyu Wakatsuki  1 , Toshiyuki Tokiwa  2 , Mayuka Higo  2 , Kenichi Nonaka  2 , Tomoyasu Hirose  2 , Rei Hokari  2 , Aki Ishiyama  2 , Masato Iwatsuki  2 , Yoshihiro Watanabe  2 , Masako Honsho  2 , Yukihiro Asami  2 , Hidehito Matsui  2 , Toshiaki Sunazuka  2 , Hideaki Hanaki  2 , Toshiaki Teruya  3 , Takahiro Ishii  4
Affiliations

A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921

Arisu Tahara et al. J Antibiot (Tokyo). 2023 Dec.

Abstract

The filamentous fungus Synnemellisia sp. strain FKR-0921 was obtained from soil collected on Kume Island, Okinawa. The MeOH extract of FKR-0921 cultured on a solid rice medium yielded a new aromatic compound, synnemellisitriol A (1). The structure, including the absolute configuration, was elucidated by spectroscopic analysis (FT-IR, NMR, and HR-ESI-MS), and the absolute configuration at C-9 of 1 was determined using the modified Mosher's method. Additionally, 1 was evaluated for its biological activities, including metallo-β-lactamase inhibitory activity, type III secretion system inhibitory activity, antimicrobial activity, antimalarial activity, and cytotoxicity.

PubMed Disclaimer

References

    1. Rosa LH, et al. Fungi in Antarctica: Diversity, ecology, effects of climate change, and bioprospection for bioactive compounds. In: Fungi of Antarctica. (Springer Nature, Switzerland, 2019), 1–17.
    1. Wiese J, Imhoff JF. Marine bacteria and fungi as promising source for new antibiotics. Drug Dev Res. 2019;80:24–27. - DOI - PubMed
    1. Amirzakariya BZ, Shakeri A. Bioactive terpenoids derived from plant endophytic fungi: An updated review (2011–2020). Phytochemistry. 2022;197:113130. - DOI - PubMed
    1. Cadamuro RD, et al. Bioactive compounds from mangrove endophytic fungus and their uses for microorganism control. J Fungi. 2021;7:455–473. - DOI
    1. Lobanovska M, Pilla G. Penicillin’s discovery and antibiotic resistance: Lessons for the future? Yale J Biol Med. 2017;90:135–145. - PubMed - PMC

Publication types

MeSH terms

LinkOut - more resources