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. 2023 Sep 13;13(9):1315.
doi: 10.3390/brainsci13091315.

Deep Medullary Vein and MRI Markers Were Related to Cerebral Hemorrhage Subtypes

Dan Wang  1   2 , Yayun Xiang  1 , Yuling Peng  1 , Peng Zeng  1 , Bang Zeng  1 , Ying Chai  1   3 , Yongmei Li  1
Affiliations

Deep Medullary Vein and MRI Markers Were Related to Cerebral Hemorrhage Subtypes

Dan Wang et al. Brain Sci. .

Abstract

Background: To explore the performance of deep medullary vein (DMV) and magnetic resonance imaging (MRI) markers in different intracerebral hemorrhage (ICH) subtypes in patients with cerebral small vessel disease (CSVD).

Methods: In total, 232 cases of CSVD with ICH were included in this study. The clinical and image data were retrospectively analyzed. Patients were divided into hypertensive arteriopathy (HTNA)-related ICH, cerebral amyloid angiopathy (CAA)-related ICH, and mixed ICH groups. The DMV score was determined in the cerebral hemisphere contralateral to the ICH.

Results: The DMV score was different between the HTNA-related and mixed ICH groups (p < 0.01). The MRI markers and CSVD burden score were significant among the ICH groups (p < 0.05). Compared to mixed ICH, HTNA-related ICH diagnosis was associated with higher deep white matter hyperintensity (DWMH) (OR: 0.452, 95% CI: 0.253-0.809, p < 0.05) and high-degree perivascular space (PVS) (OR: 0.633, 95% CI: 0.416-0.963, p < 0.05), and CAA-related ICH diagnosis was associated with increased age (OR: 1.074; 95% CI: 1.028-1.122, p = 0.001). The DMV score correlated with cerebral microbleed (CMB), PVS, DWMH, periventricular white matter hyperintensity (PWMH), and CSVD burden score (p < 0.05) but not with lacuna (p > 0.05). Age was an independent risk factor for the severity of DMV score (OR: 1.052; 95% CI: 0.026-0.076, p < 0.001).

Conclusion: DMV scores, CSVD markers, and CSVD burden scores were associated with different subtypes of ICH. In addition, DMV scores were associated with the severity of CSVD and CSVD markers.

Keywords: MRI markers; cerebral small vessel disease; deep medullary vein; intracerebral hemorrhage.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Enrollment flow chart and study inclusion and exclusion criteria.
Figure 2
Figure 2
Deep medullary vein scoring system. (A) shows score 0 with continuous vein, uniform signal of vein; (B) shows score 1 with continuous veins, but one or more veins have uneven signals; (C) shows score 2 with one or more veins are discontinuous and with faint visibility; and (D) shows score 3 with no continuous veins found.
Figure 2
Figure 2
Deep medullary vein scoring system. (A) shows score 0 with continuous vein, uniform signal of vein; (B) shows score 1 with continuous veins, but one or more veins have uneven signals; (C) shows score 2 with one or more veins are discontinuous and with faint visibility; and (D) shows score 3 with no continuous veins found.
See this image and copyright information in PMC

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