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Review
. 2023 Sep 16;12(9):1772.
doi: 10.3390/antiox12091772.

The Role of Oxidative Stress in Kidney Injury

Nejc Piko  1 , Sebastjan Bevc  2   3 , Radovan Hojs  2   3 , Robert Ekart  1   3
Affiliations
Review

The Role of Oxidative Stress in Kidney Injury

Nejc Piko et al. Antioxidants (Basel). .

Abstract

Acute kidney injury and chronic kidney disease are among the most common non-communicable diseases in the developed world, with increasing prevalence. Patients with acute kidney injury are at an increased risk of developing chronic kidney disease. One of kidney injury's most common clinical sequelae is increased cardiovascular morbidity and mortality. In recent years, new insights into the pathophysiology of renal damage have been made. Oxidative stress is the imbalance favoring the increased generation of ROS and/or reduced body's innate antioxidant defense mechanisms and is of pivotal importance, not only in the development and progression of kidney disease but also in understanding the enhanced cardiovascular risk in these patients. This article summarizes and emphasizes the role of oxidative stress in acute kidney injury, various forms of chronic kidney disease, and also in patients on renal replacement therapy (hemodialysis, peritoneal dialysis, and after kidney transplant). Additionally, the role of oxidative stress in the development of drug-related nephrotoxicity and also in the development after exposure to various environmental and occupational pollutants is presented.

Keywords: acute kidney injury; acute tubular necrosis; chronic kidney disease; oxidative stress; reactive oxygen species.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The most important risk factors for the development of acute kidney injury.
Figure 2
Figure 2
The spectrum of kidney injury in the context of oxidative stress.
See this image and copyright information in PMC

References

    1. Muntner P., He J., Astor B.C., Folsom A.R., Coresh J. Traditional and nontraditional risk factors predict coronary heart disease in chronic kidney disease: Results from the atherosclerosis risk in communities study. J. Am. Soc. Nephrol. 2005;16:529–538. doi: 10.1681/ASN.2004080656. - DOI - PubMed
    1. Tomsa A.M., Alexa A.L., Junie M.L., Rachisan A.L., Ciumarnean L. Oxidative stress as a potential target in acute kidney injury. PeerJ. 2019;7:e8046. doi: 10.7717/peerj.8046. - DOI - PMC - PubMed
    1. Page M.J., McKenzie J.E., Bossuyt P.M., Boutron I., Hoffmann T.C., Mulrow C.D., Shamseer L., Tetzlaff J.M., Akl E.A., Brennan S.E., et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. Rev. Española Cardiol. 2021;74:790–799. doi: 10.1016/j.recesp.2021.06.016. - DOI - PMC - PubMed
    1. Khadzhynov D., Schmidt D., Hardt J., Rauch G., Gocke P., Eckardt K.U., Schmidt-Ott K.M. The Incidence of Acute Kidney Injury and Associated Hospital Mortality. Dtsch. Arztebl. Int. 2019;116:397–404. doi: 10.3238/arztebl.2019.0397. - DOI - PMC - PubMed
    1. Hoste E.A., Bagshaw S.M., Bellomo R., Cely C.M., Colman R., Cruz D.N., Edipidis K., Forni L.G., Gomersall C.D., Govil D., et al. Epidemiology of acute kidney injury in critically ill patients: The multinational AKI-EPI study. Intensive Care Med. 2015;41:1411–1423. doi: 10.1007/s00134-015-3934-7. - DOI - PubMed

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